Evidence map›Paper›PMID 35786622›Full record

ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2022

Interaction of CCND2, CDKN1A, and POLD3 Variants in Mexican Patients with Colorectal Cancer.

Carlos Rogelio Alvizo-Rodríguez, Beatriz Armida Flores-López, María de la Luz Ayala-Madrigal, Miriam Partida-Pérez, Nelly Margarita Macías-Gómez, Jorge Peregrina-Sandoval, Alexis Sayuri Suárez-Villanueva, José Miguel Moreno-Ortiz, Sergio Cervantes-Ortiz, Víctor Manuel Maciel-Gutiérre and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Association of Genetic Variants at theInternational journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Carlos Rogelio Alvizo-RodríguezDepartment of Molecular Biology and Genomics, Doctorado en Genética Humana e Instituto de Genética Humana "Dr. Enrique Corona Rivera", University of Guadalajara, Jalisco, México.
Beatriz Armida Flores-LópezDepartment of Molecular Biology and Genomics, Doctorado en Genética Humana e Instituto de Genética Humana "Dr. Enrique Corona Rivera", University of Guadalajara, Jalisco, México.
María de la Luz Ayala-MadrigalDepartment of Molecular Biology and Genomics, Doctorado en Genética Humana e Instituto de Genética Humana "Dr. Enrique Corona Rivera", University of Guadalajara, Jalisco, México.
Miriam Partida-PérezLaboratory of Molecular and Genomic Biology, University of Guadalajara, Puerto Vallarta, Jalisco, México.
Nelly Margarita Macías-GómezHuman Genetics Laboratory, University of Guadalajara, Ciudad Guzmán, Jalisco, México.
Jorge Peregrina-SandovalDepartment of Cellular and Molecular Biology, Institute of Cellular Physiology, University of Guadalajara Faculty of Biological and Agricultural Sciences, Zapopan, Jalisco, México.
Alexis Sayuri Suárez-VillanuevaDepartment of Cellular and Molecular Biology, Institute of Cellular Physiology, University of Guadalajara Faculty of Biological and Agricultural Sciences, Zapopan, Jalisco, México; Universidad del Valle de México Faculty of Health Sciences, Campus Zapopan, Zapopan, Jalisco, México.
José Miguel Moreno-OrtizDepartment of Molecular Biology and Genomics, Doctorado en Genética Humana e Instituto de Genética Humana "Dr. Enrique Corona Rivera", University of Guadalajara, Jalisco, México.
Sergio Cervantes-OrtizDepartment of Colon and Rectum, Civil de Guadalajara Dr. Juan I. Menchaca Hospital, Guadalajara, Jalisco, México; Department of Health Sciences, University of Guadalajara, Tepatitlán de Morelos, Jalisco, México.
Víctor Manuel Maciel-GutiérreDepartment of Colon and Rectum, Civil de Guadalajara Dr. Juan I. Menchaca Hospital, Guadalajara, Jalisco, México.
Melva Gutiérrez-AnguloDepartment of Molecular Biology and Genomics, Doctorado en Genética Humana e Instituto de Genética Humana "Dr. Enrique Corona Rivera", University of Guadalajara, Jalisco, México; Department of Health Sciences, University of Guadalajara, Tepatitlán de Morelos, Jalisco, México.
Universidad de Guadalajara · MXHospital Civil de Guadalajara · MXUniversity of the Valley of Atemajac · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer is the second cause of death by cancer around the world. Sporadic colorectal cancer is the most frequent (75%), and it is produced by the interaction of environmental, epigenetic, and genetic factors. The accumulation of single-nucleotide variants in genes associated with cell proliferation, DNA repair, and/or apoptosis could confer a risk to cancer. The aim of this study was to analyze the gene-gene interactions among CCND2 (rs3217901), CDKN1A (rs1059234 and rs1801270), and POLD3 (rs3824999) variants in Mexican patients with colorectal cancer.

methodsWe collected peripheral blood samples from 185 patients with sporadic colorectal cancer before treatment and from 185 unrelated blood donors as the reference group; all participants signed an informed consent form. DNA extraction was performed by Miller and Cetyltrimethylammonium bromide (CTAB)/ Dodecyltrimethylammonium bromide (DTAB) methods. Polymerase chain reaction- restriction fragment length polymorphism followed by polyacrylamide gel electrophoresis stained with AgNO3 methods were used to identify the variants rs3217901, rs1059234, rs1801270, and rs3824999. Odds ratio and single-nucleotide variant interaction were determined by single-locus analysis and Multifactorial Dimensionality Reduction software, respectively.

resultsNo association was found for CCND2 and CDKN1A variants; yet, a significant association for the GG genotype, G allele, and recessive and additive models for the POLD3 variant was observed (P < .05). The single-nucleotide variant-single-nucleotide variant interaction revealed the combination rs1059234, rs3217901, and rs3824999 as the best model and the comparison showed an increased risk (P < .05).

conclusionSingle-locus and gene-gene interaction analyses disclosed that both the rs3824999 (POLD3) variant and the combination of rs3217901 (CCND2), rs1059234 (CDKN1A), and rs3824999 (POLD3) genotypes increase the risk for colorectal cancer in Mexican population.

Indexed as

Colorectal NeoplasmsPolymorphism, Single NucleotideCase-Control StudiesCyclin D2Cyclin-Dependent Kinase Inhibitor p21DNA Polymerase IIIGenotypeHumansMexicoNucleotidesCCND2 protein, humanCDKN1A protein, humanCyclin D2Cyclin-Dependent Kinase Inhibitor p21DNA Polymerase IIINucleotidesPOLD3 protein, human

Identifiers

PMID35786622
PMCPMC9317789
OpenAlexW4281570976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.