ArticleIEEE transactions on bio-medical engineering2022
Direct Visualization and Quantitative Imaging of Small Airway Anatomy In Vivo Using Deep Learning Assisted Diffractive OCT.
Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Mapping airway smooth muscle remodellingERJ open research · 2026Article
- Recent advances in artificial intelligence across interventional pulmonology: a narrative review.Journal of thoracic disease · 2026Review
- Identification of imaging-based pulmonary and extrapulmonary treatable traits in COPD: a review.Frontiers in medicine · 2026Review
- Automated detection of radiolucent foreign body aspiration on chest CT using deep learning.NPJ digital medicine · 2025Article
- An Old Dog Performing the Same Old Tricks: The Role of TGF-β Receptor in Tissue Factor Release and Extracellular Vesicle Formation.American journal of respiratory cell and molecular biology · 2025Article
- Bimodal Tactile Tomography with Bayesian Sequential Palpation for Intracavitary Microstructure Profiling and Segmentation.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Advances in artificial intelligence applications for the management of chronic obstructive pulmonary disease.Frontiers in medicine · 2025Review
- Motor-free telerobotic endomicroscopy for steerable and programmable imaging in complex curved and localized areas.Nature communications · 2024Article
- PneumaOCT: Pneumatic optical coherence tomography endoscopy for targeted distortion-free imaging in tortuous and narrow internal lumens.Science advances · 2024Article
- Translating endobronchial optical coherence tomography to clinical practice.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Multimodal Diagnostics of Changes in Rat Lungs after Vaping.Diagnostics (Basel, Switzerland) · 2023Article
- Optical clearing and testing of lung tissue using inhalation aerosols: prospects for monitoring the action of viral infections.Biophysical reviews · 2022Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
OBJECTIVE/
backgroundIn vivo imaging and quantification of the microstructures of small airways in three dimensions (3D) allows a better understanding and management of airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). At present, the resolution and contrast of the currently available conventional optical coherence tomography (OCT) imaging technologies operating at 1300 nm remain challenging to directly visualize the fine microstructures of small airways in vivo.
methodsWe developed an ultrahigh-resolution diffractive endoscopic OCT at 800 nm to afford a resolving power of 1.7 µm (in tissue) with an improved contrast and a custom deep residual learning based image segmentation framework to perform accurate and automated 3D quantification of airway anatomy.
resultsThe 800-nm diffractive OCT enabled the direct delineation of the structural components in the small airway wall in vivo. We further first demonstrated the 3D anatomic quantification of critical tissue compartments of small airways in sheep using the automated segmentation method.
conclusionThe deep learning assisted diffractive OCT provides a unique ability to access the small airways, directly visualize and quantify the important tissue compartments, such as airway smooth muscle, in the airway wall in vivo in 3D. SIGNIFICANCE: These pilot results suggest a potential technology for calculating volumetric measurements of small airways in patients in vivo.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.