ArticleeLife2022
Visualizing synaptic dopamine efflux with a 2D composite nanofilm.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Synapse-like specializations at dopamine release sites orchestrate efficient and precise neuromodulatory signaling.Science advances · 2026Article
- Optical Detection of Cellular Signals at Material Interfaces.Advanced healthcare materials · 2026Review
- Acute partner loss enhances social motivation and nucleus accumbens dopamine release in prairie voles.bioRxiv : the preprint server for biology · 2026Article
- Protocol for fluorescent false neurotransmitter live imaging of dopamine release dynamics from individual synapses in acute brain slices.STAR protocols · 2026Article
- Illuminating the Future of Catecholamine Detection.Journal of neurochemistry · 2026Review
- The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Quantifying Population Reversibility of Sensor Performance in Multi-Cycle Single-Sensor Recovery Assay.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Adapting a Two-Photon Scanning Microscope for Simultaneous Single-Photon Imaging of an Infrared Dopamine Sensor.eNeuro · 2026Article
- Neurochemical imaging reveals changes in dopamine dynamics with photoperiod in a seasonally social vole species.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adapting a two-photon scanning microscope for simultaneous single-photon imaging of an infrared dopamine sensor.bioRxiv : the preprint server for biology · 2026Article
- The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.bioRxiv : the preprint server for biology · 2025Article
- Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis.Nature communications · 2025Article
- Discrete spatiotemporal encoding of striatal dopamine transmission.Science (New York, N.Y.) · 2025Article
- Nanosensor-based imaging of realtime dopamine release in neurons derived from iPSCs of patients with Parkinson's disease.Materials today. Bio · 2025Article
- Redox dye-mediated fluorescence energy transfer of carbon nanotube-based nanosensors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Cortical acetylcholine dynamics are predicted by cholinergic axon activity and behavior state.Cell reports · 2024Article
- A modular chemigenetic calcium indicator for multiplexed in vivo functional imaging.Nature methods · 2024Article
- A chemogenetic approach for dopamine imaging with tunable sensitivity.Nature communications · 2024Article
- Near-infrared nanosensors enable optical imaging of oxytocin with selectivity over vasopressin in acute mouse brain slices.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Chemical neurotransmission constitutes one of the fundamental modalities of communication between neurons. Monitoring release of these chemicals has traditionally been difficult to carry out at spatial and temporal scales relevant to neuron function. To understand chemical neurotransmission more fully, we need to improve the spatial and temporal resolutions of measurements for neurotransmitter release. To address this, we engineered a chemi-sensitive, two-dimensional composite nanofilm that facilitates visualization of the release and diffusion of the neurochemical dopamine with synaptic resolution, quantal sensitivity, and simultaneously from hundreds of release sites. Using this technology, we were able to monitor the spatiotemporal dynamics of dopamine release in dendritic processes, a poorly understood phenomenon. We found that dopamine release is broadcast from a subset of dendritic processes as hotspots that have a mean spatial spread of ≈ 3.2 µm (full width at half maximum [FWHM]) and are observed with a mean spatial frequency of one hotspot per ≈ 7.5 µm of dendritic length. Major dendrites of dopamine neurons and fine dendritic processes, as well as dendritic arbors and dendrites with no apparent varicose morphology participated in dopamine release. Remarkably, these release hotspots co-localized with Bassoon, suggesting that Bassoon may contribute to organizing active zones in dendrites, similar to its role in axon terminals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.