ArticleJournal of the American Chemical Society2022
DNA Strand-Displacement Temporal Logic Circuits.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Spatially Encoded Protocell Network for Non-Cascaded Parallel Biocomputation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- DNA-Based Boolean Logic Gates for Molecular Computation and Biosensing: A Critical Review.Molecular biotechnology · 2026Review
- Enzymatic DNA Reaction Networks for Orchestrating Stimuli-Dependent Temporal Molecular Pulse.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A general and scalable DNA nano-chip with a fully localized architecture enables biocomputing in living cells and precisely induces cell apoptosis.Chemical science · 2026Article
- Reset-free DNA logic circuits for real-time input processing and memory.Science advances · 2026Article
- Solving Minimum Spanning Tree Problems Based on DNA Chemical Reaction Networks.Combinatorial chemistry & high throughput screening · 2026Article
- Enzyme-driven triplex structure-based DNA logic circuits.Journal of nanobiotechnology · 2025Article
- Intelligent molecular logic computing toolkits: nucleic acid-based construction, functionality, and enhanced biosensing applications.Chemical science · 2025Review
- Designing a DNA synchronizer for compact single-rail DNA logic circuits.Science advances · 2025Article
- DNA Sequential Logic Circuits for Reversible Counters and Dynamic Biomolecular Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Localized Scalable DNA Logic Circuit System Based on the DNA Origami Surface.International journal of molecular sciences · 2025Article
- High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register.ACS central science · 2024Article
- Scalable DNA recognition circuits based on DNA strand displacement.Nanoscale advances · 2024Article
- Temporally controlled multistep division of DNA droplets for dynamic artificial cells.Nature communications · 2024Article
- Aptamer-Based DNA Allosteric Switch for Regulation of Protein Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- An Exo III-powered closed-loop DNA circuit architecture for biosensing/imaging.Mikrochimica acta · 2024Article
- DNA-empowered synthetic cells as minimalistic life forms.Nature reviews. Chemistry · 2024Review
- Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications.Smart molecules : open access · 2024Review
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Lipid vesicle-based molecular robots.Lab on a chip · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Molecular circuits capable of processing temporal information are essential for complex decision making in response to both the presence and history of a molecular environment. A particular type of temporal information that has been recognized to be important is the relative timing of signals. Here we demonstrate the strategy of temporal memory combined with logic computation in DNA strand-displacement circuits capable of making decisions based on specific combinations of inputs as well as their relative timing. The circuit encodes the timing information on inputs in a set of memory strands, which allows for the construction of logic gates that act on current and historical signals. We show that mismatches can be employed to reduce the complexity of circuit design and that shortening specific toeholds can be useful for improving the robustness of circuit behavior. We also show that a detailed model can provide critical insights for guiding certain aspects of experimental investigations that an abstract model cannot. We envision that the design principles explored in this study can be generalized to more complex temporal logic circuits and incorporated into other types of circuit architectures, including DNA-based neural networks, enabling the implementation of timing-dependent learning rules and opening up new opportunities for embedding intelligent behaviors into artificial molecular machines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.