Evidence map›Paper›PMID 35785480›Full record

ArticleObesity (Silver Spring, Md.)2022

Reversal of obesity development in Ceacam1

Zhifang Zhang, Deirdre La Placa, Gabriel Gugiu, Alyssa Thunen, Keith Le, John E Shively

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Regulation of lipid storage and inflammation in the liver by CEACAM1.European journal of clinical investigation · 2024
    Review
  2. Article
  3. Review
  4. Heart Uptake of [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  5. Reversal of obesity development in Ceacam1Obesity (Silver Spring, Md.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhifang ZhangDepartment of Immunology & Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Cancer Center, Duarte, California, USA.
Deirdre La PlacaDepartment of Immunology & Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Cancer Center, Duarte, California, USA.
Gabriel GugiuDepartment of Immunology & Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Cancer Center, Duarte, California, USA.
Alyssa ThunenDepartment of Immunology & Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Cancer Center, Duarte, California, USA.
Keith LeDepartment of Immunology & Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Cancer Center, Duarte, California, USA.
John E ShivelyDepartment of Immunology & Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Cancer Center, Duarte, California, USA.ORCID 0000-0002-7763-770X
City Of Hope National Medical Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

objectiveAlthough Ceacam1

methodsThis study analyzed Ceacam1

resultsMale Ceacam1

conclusionsCEACAM1 expression in both the liver and immune cells regulates obesity and lipid storage pathways in the liver. Bone marrow reconstitution of the immune system or introduction of the human CEACAM1 gene can fully or partially reverse the phenotype.

Indexed as

Bone Marrow TransplantationCell Adhesion MoleculesAnimalsAntigens, CDCarcinoembryonic AntigenHumansMaleMiceObesityTranscription FactorsAntigens, CDCarcinoembryonic AntigenCD66 antigensCeacam1 protein, mouseCell Adhesion MoleculesTranscription Factors

Identifiers

PMID35785480
PMCPMC9541698
OpenAlexW4283801216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.