Evidence map›Paper›PMID 35785041›Full record

ReviewRegenerative therapy2022

Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan.

Yusuke Shimizu, Edward Hosea Ntege, Hiroshi Sunami

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regenerative therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Extracellular vesicles and epigenetic aging clocks in tissue aging: an exosome-focused conceptual framework with a focus on skin.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Status of research on the development and regeneration of hair follicles.International journal of medical sciences · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yusuke ShimizuDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, 903-0215 Okinawa, Japan.
Edward Hosea NtegeDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, 903-0215 Okinawa, Japan.
Hiroshi SunamiCenter for Advanced Medical Research, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, 903-0215 Okinawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current trends indicate a growing interest among healthcare specialists and the public in the use of regenerative medicine-based approaches for skin regeneration. The approaches are categorised in either cell-based or cell-free therapies and are reportedly safe and effective. Cell-based therapies include mesenchymal stem cells (MSCs), tissue induced pluripotent stem cells (iPSCs), fibroblast-based products, and blood-derived therapies, such as those employing platelet-rich plasma (PRP) products. Cell-free therapies primarily involve the use of MSC-derived extracellular vesicles/exosomes. MSCs are isolated from various tissues, such as fat, bone marrow, umbilical cord, menstrual blood, and foetal skin, and expanded

Indexed as

AD-MSCs, adipose MSCsAutologous transplantationbFGF, fibroblast growth factor-basicBM-MSCs, bone marrow MSCsCell-based therapyCell-free therapyeMSC, endometrial mesenchymal stem-like cellsFD-MSC, fatal dermis MSCsIGF, insulin-like growth factoriPSCs, induced pluripotent stem cellsKGF, keratinocyte growth factorMesenchymal stem cellsMMP-12, matrix metalloproteinase-12MSC-CM, MSC-derived conditioned mediaMSC-EVs, MSC-derived extracellular vesiclesMSC-exo, MSC-derived exosomesMSCs, mesenchymal stem cellsNF-κB, nuclear factor-κBPRP, platelet-rich plasmaSkin ageingSkin regenerationTNF-α, tumour necrosis factor alphaTSG-6, tumour necrosis factor-stimulated gene-6UC-MSC, umbilical cord MSCsUVB, ultraviolet-BVEGF, vascular endothelial growth factor

Identifiers

PMID35785041
PMCPMC9213559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.