Evidence map›Paper›PMID 35784885›Full record

ArticleFrontiers in physiology2022

Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases.

Mafalda S L Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A Perrino, Violeta N Mutafova-Yambolieva

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mafalda S L Aresta BrancoDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, United States.
Alejandro Gutierrez CruzDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, United States.
Jacob DaytonDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, United States.
Brian A PerrinoDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, United States.
Violeta N Mutafova-YambolievaDepartment of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, United States.
University of Nevada, Reno · US

Funding

Urothelial Purinergic Signaling During Bladder FillingR01DK119482 · NIDDK · UNIVERSITY OF NEVADA RENO · PI Violeta N. Mutafova-Yambolieva · 2020 to 2026
$3.3M
NIDDK NIH HHS R01 DK119482
6 · The paper itself

Abstract

Prior studies suggest that urothelium-released adenosine 5'-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many cell types in the lamina propria (LP), including afferent neurons, and might also be important for direct mechanosensitive signaling between urothelium and detrusor. The excitatory action of ATP is terminated by enzymatic hydrolysis, which subsequently produces bioactive metabolites. We examined possible mechanosensitive mechanisms of ATP hydrolysis in the LP by determining the degradation of 1,

Indexed as

ADPATP-adenosine triphosphateATP hydrolysisbladderlamina propria (LP)nucleotidasespurine nucleotidesurothelium

Identifiers

PMID35784885
PMCPMC9246094
OpenAlexW4283011515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.