Evidence map›Paper›PMID 35784862›Full record

ArticleFrontiers in physiology2022

Effects of Hydroxyurea on Skeletal Muscle Energetics and Function in a Mildly Anemic Mouse Model.

Constance P Michel, Laurent A Messonnier, Benoit Giannesini, Benjamin Chatel, Christophe Vilmen, Yann Le Fur, David Bendahan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Constance P MichelCRMBM, CNRS, Aix Marseille University, Marseille, France.
Laurent A MessonnierLaboratoire Interuniversitaire de Biologie de la Motricité, Université Savoie Mont Blanc, Chambéry, France.
Benoit GiannesiniCRMBM, CNRS, Aix Marseille University, Marseille, France.
Benjamin ChatelCRMBM, CNRS, Aix Marseille University, Marseille, France.
Christophe VilmenCRMBM, CNRS, Aix Marseille University, Marseille, France.
Yann Le FurCRMBM, CNRS, Aix Marseille University, Marseille, France.
David BendahanCRMBM, CNRS, Aix Marseille University, Marseille, France.
Aix-Marseille Université · FRCentre de Résonance Magnétique Biologique et Médicale · FRCentre National de la Recherche Scientifique · FRLaboratoire Interuniversitaire de Biologie de la Motricité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxyurea (HU) is a ribonucleotide reductase inhibitor most commonly used as a therapeutic agent in sickle cell disease (SCD) with the aim of reducing the risk of vaso-occlusion and improving oxygen transport to tissues. Previous studies suggest that HU may be even beneficial in mild anemia. However, the corresponding effects on skeletal muscle energetics and function have never been reported in such a mild anemia model. Seventeen mildly anemic HbAA Townes mice were subjected to a standardized rest-stimulation (transcutaneous stimulation)-protocol while muscle energetics using

Indexed as

anemiahydroxyureamagnetic resonance imagingmagnetic resonance spectroscopyskeletal muscle energeticsskeletal muscle function

Identifiers

PMID35784862
PMCPMC9240423
OpenAlexW4282961455

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.