Non-carbapenemase producing carbapenem-resistant

Claire R Burbick, Trevor L Alexander, Rebecca Wolking, Tamara Gull, Olgica Ceric, Renate Reimschuessel

Open access · greenAbstract read

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 70% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Claire R BurbickWashington Animal Disease Diagnostic Laboratory, Washington State University, 1940 SE Olympia Ave, Pullman, Washington 99164, USA (Burbick, Alexander, Wolking); Department of Veterinary Microbiology and Pathology, Washington State University, PO Box 647040, Pullman, Washington 99164, USA (Burbick); Veterinary Medical Diagnostic Laboratory, University of Missouri, PO Box 6023, Columbia, Missouri 65205, USA (Gull); Veterinary Laboratory Investigation and Response Network, Center for Veterinary Medicine, United States Food and Drug Administration, 8491 Muirkirk Road, Laurel, Maryland 20708, USA (Ceric, Reimschuessel).

Trevor L AlexanderWashington Animal Disease Diagnostic Laboratory, Washington State University, 1940 SE Olympia Ave, Pullman, Washington 99164, USA (Burbick, Alexander, Wolking); Department of Veterinary Microbiology and Pathology, Washington State University, PO Box 647040, Pullman, Washington 99164, USA (Burbick); Veterinary Medical Diagnostic Laboratory, University of Missouri, PO Box 6023, Columbia, Missouri 65205, USA (Gull); Veterinary Laboratory Investigation and Response Network, Center for Veterinary Medicine, United States Food and Drug Administration, 8491 Muirkirk Road, Laurel, Maryland 20708, USA (Ceric, Reimschuessel).

Rebecca WolkingWashington Animal Disease Diagnostic Laboratory, Washington State University, 1940 SE Olympia Ave, Pullman, Washington 99164, USA (Burbick, Alexander, Wolking); Department of Veterinary Microbiology and Pathology, Washington State University, PO Box 647040, Pullman, Washington 99164, USA (Burbick); Veterinary Medical Diagnostic Laboratory, University of Missouri, PO Box 6023, Columbia, Missouri 65205, USA (Gull); Veterinary Laboratory Investigation and Response Network, Center for Veterinary Medicine, United States Food and Drug Administration, 8491 Muirkirk Road, Laurel, Maryland 20708, USA (Ceric, Reimschuessel).

Tamara GullWashington Animal Disease Diagnostic Laboratory, Washington State University, 1940 SE Olympia Ave, Pullman, Washington 99164, USA (Burbick, Alexander, Wolking); Department of Veterinary Microbiology and Pathology, Washington State University, PO Box 647040, Pullman, Washington 99164, USA (Burbick); Veterinary Medical Diagnostic Laboratory, University of Missouri, PO Box 6023, Columbia, Missouri 65205, USA (Gull); Veterinary Laboratory Investigation and Response Network, Center for Veterinary Medicine, United States Food and Drug Administration, 8491 Muirkirk Road, Laurel, Maryland 20708, USA (Ceric, Reimschuessel).

Olgica CericWashington Animal Disease Diagnostic Laboratory, Washington State University, 1940 SE Olympia Ave, Pullman, Washington 99164, USA (Burbick, Alexander, Wolking); Department of Veterinary Microbiology and Pathology, Washington State University, PO Box 647040, Pullman, Washington 99164, USA (Burbick); Veterinary Medical Diagnostic Laboratory, University of Missouri, PO Box 6023, Columbia, Missouri 65205, USA (Gull); Veterinary Laboratory Investigation and Response Network, Center for Veterinary Medicine, United States Food and Drug Administration, 8491 Muirkirk Road, Laurel, Maryland 20708, USA (Ceric, Reimschuessel).

Renate ReimschuesselWashington Animal Disease Diagnostic Laboratory, Washington State University, 1940 SE Olympia Ave, Pullman, Washington 99164, USA (Burbick, Alexander, Wolking); Department of Veterinary Microbiology and Pathology, Washington State University, PO Box 647040, Pullman, Washington 99164, USA (Burbick); Veterinary Medical Diagnostic Laboratory, University of Missouri, PO Box 6023, Columbia, Missouri 65205, USA (Gull); Veterinary Laboratory Investigation and Response Network, Center for Veterinary Medicine, United States Food and Drug Administration, 8491 Muirkirk Road, Laurel, Maryland 20708, USA (Ceric, Reimschuessel).

Washington State University · US

Funding

FDA Vet-LIRN Veterinary Diagnostic Laboratory ProgramU18FD006180 · FDA · WASHINGTON STATE UNIVERSITY · PI Kevin Roy Snekvik · 2017 to 2026

$660k

FDA HHS U18 FD006180FDA HHS U18 FD006453

6 · The paper itself

Abstract

Objective: Carbapenems are broad-spectrum β-lactams with excellent activity against multidrug-resistant (MDR) Animal: Canine. Procedure: Whole genome sequencing and phenotypic antimicrobial susceptibility testing was performed on a Results: Antimicrobial susceptibility testing identified phenotypic resistance to imipenem and meropenem. Phenotypic detection of carbapenemase production was negative. Whole genome sequencing identified efflux pump genes associated with carbapenem resistance and point mutations in membrane porin genes. No carbapenemase gene was identified. Conclusion: Phenotypic antimicrobial susceptibility testing identified the Clinical significance: Currently, there is limited use of carbapenem antimicrobial drugs in veterinary medicine, and practitioners may be unfamiliar or unaware of this type of resistance, its significance on routine antimicrobial susceptibility test reports, and implications for antimicrobial therapy and public health. Carbapenem-resistant

Indexed as

CarbapenemsUrinary TractAnimalsDogsKlebsiella pneumoniaeMicrobial Sensitivity TestsPorinsCarbapenemsPorins

Identifiers

PMID35784769

PMCPMC9207975

OpenAlexW4283831681

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.