Evidence map›Paper›PMID 35784742›Full record

ArticleFrontiers in pharmacology2022

A Randomized Controlled Dose-Escalation Study of LY06006, a Recombinant Humanized Monoclonal Antibody to RANKL, in Chinese Healthy Adults.

Suping Niu, Min Chen, Diqin Yan, Xiangxing Liu, Shuren Guo, Lun Ou, Huaying Fan, Jie Lv, Qian Wang, Wenliang Dong and 11 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Body weight predicts denosumab pharmacodynamic duration: a real-world longitudinal cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Suping NiuDepartment of Science and Research, Peking University People's Hospital, Beijing, China.
Min ChenDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Diqin YanDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Xiangxing LiuDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Shuren GuoShandong Boan Biotechnology Co., Ltd., Yantai, China.
Lun OuBeijing United-Power Pharma Tech Co., Ltd., Beijing, China.
Huaying FanDepartment of Science and Research, Peking University People's Hospital, Beijing, China.
Jie LvDepartment of Intensive Care Units, Peking University People's Hospital, Beijing, China.
Qian WangDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Wenliang DongDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Lin XiaDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Simin WangDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Gang LiuDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Qun GuDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.
Danjie GuoDepartment of Science and Research, Peking University People's Hospital, Beijing, China.
Hongxia LiuShanghai University of Traditional Chinese Medicine, Shanghai, China.
Huiying RaoDepartment of Science and Research, Peking University People's Hospital, Beijing, China.
Qingshan ZhengThe Center for Drug Clinical Research of Shanghai University of TCM, Shanghai, China.
Xiaoyan NieDepartment of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical, Peking University, Beijing, China.
Haifeng SongState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Yi FangDepartment of Pharmacy, Peking University People's Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

denosumabimmunogenicityosteoporosispharmacodynamicspharmacokineticsRANK/RANKL

Identifiers

PMID35784742
PMCPMC9240259

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.