Evidence map›Paper›PMID 35784683›Full record

ArticleFrontiers in pharmacology2022

Influence of Gender, Body Mass Index, and Age on the Pharmacokinetics of Itraconazole in Healthy Subjects: Non-Compartmental Versus Compartmental Analysis.

Milijana N Miljković, Nemanja Rančić, Aleksandra Kovačević, Bojana Cikota-Aleksić, Ivan Skadrić, Vesna Jaćević, Momir Mikov, Viktorija Dragojević-Simić

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Milijana N MiljkovićCentre for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia.
Nemanja RančićCentre for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia.
Aleksandra KovačevićCentre for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia.
Bojana Cikota-AleksićCentre for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia.
Ivan SkadrićInstitute of Microbiology and Immunology, University of Belgrade, Faculty of Medicine, Belgrade, Serbia.
Vesna JaćevićMedical Faculty of the Military Medical Academy, University of Defence in Belgrade, Belgrade, Serbia.
Momir MikovInstitute for Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Viktorija Dragojević-SimićCentre for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia.
University of Defence · RSMilitary Medical Academy · RSUniversity of Belgrade · RSUniversity of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Itraconazole is a triazole antifungal agent with highly variable pharmacokinetics, with not yet fully identified factors as the source of this variability. Our study aimed to examine the influence of body mass index, gender, and age on the first dose pharmacokinetics of itraconazole in healthy subjects, using pharmacokinetic modeling, non-compartmental

Indexed as

agebody mass indexcompartmental analysisgendergenetic polymorphismhydroxy-itraconazoleitraconazolenon-compartmental analysis

Identifiers

PMID35784683
PMCPMC9240599
OpenAlexW4282968987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.