ArticleEClinicalMedicine2022
Global epidemiology of vaccine-derived poliovirus 2016-2021: A descriptive analysis and retrospective case-control study.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Response to a vaccine-derived poliovirus type 1 event - Sichuan, China, 2024.BMC infectious diseases · 2026Article
- Rotavirus mucosal immunology: insights and research priorities from an international convening in Liverpool, March 2024.NPJ vaccines · 2026Article
- Article
- Article
- Early Detection and Surveillance of Infectious Disease Outbreaks in Nigeria : Integrating Nigerian Pidgin English (NPE) into the EPIWATCHJournal of medical systems · 2026Article
- The global threat of vaccine-preventable neurological diseases.Nature reviews. Neurology · 2026Review
- A review of post-exposure strategies for high-consequence viral pathogens in the laboratory.Clinical microbiology reviews · 2025Review
- Investigation and response to a type 3 vaccine-derived poliovirus detected in an infant with hand, foot, and mouth disease - Guangdong, China, 2023.Journal of health, population, and nutrition · 2025Article
- Polio Resurgence at Next Door - A Potential Threat to India.Indian journal of pediatrics · 2025Article
- "Build back the confidence": qualitative exploration of community experiences with polio vaccination in the Covid-19 context in Cameroon and Ethiopia.BMC public health · 2024Article
- Article
- Prevalence of vaccine-derived poliovirus in sewage waters in Maiduguri, Borno State, Nigeria.Le infezioni in medicina · 2024Article
- [Failure of poliomyelitis eradication campaign with oral vaccine: there's no vaccination without adherence].Medecine tropicale et sante internationale · 2023Article
- Vaccine Refusal: A Major, Underestimated Obstacle for the Poliomyelitis Eradication Initiative.The American journal of tropical medicine and hygiene · 2023Article
- Vaccine-derived polio in Peru after 32 years of elimination: reflections on the routine childhood immunisation coverages.Lancet regional health. Americas · 2023Article
- Article
- Asymptomatic immunodeficiency-associated vaccine-derived poliovirus infections in two UK children.Nature communications · 2023Article
- Response to back-to-back outbreaks of circulating vaccine-derived poliovirus type 2 in two nomadic pastoralist settlements in Oti Region, Ghana-2019.Archives of public health = Archives belges de sante publique · 2023Article
- Vaccine Derived Poliovirus (VDPV).Le infezioni in medicina · 2023Review
- The growing threat of wild poliovirus 1 and vaccine-derived cases in the COVID-19 era.The Lancet. Infectious diseases · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vaccine derived poliovirus (VDPV) remains a major barrier to polio eradication, and recent growing emergences are concerning. This paper presents the global epidemiology of circulating VDPV (cVDPV) by exploring associations between demographic and socioeconomic factors with its recent rise. Methods: Data on reported cVDPV cases and isolates between January 1 2016 and June 30 2021 were compiled from EPIWATCH, an open-source observatory for outbreak scanning and analysis, the World Health Organisation (WHO) and ProMed, and analysed descriptively. Reports containing cVDPV case information were included while duplicates and defective links were excluded. Data collection occurred from April 5 2021 to July 16 2021. To identify factors associated with cVDPV, a retrospective case-control study comparing socioeconomic profiles of countries which reported cVDPV with those that did not was undertaken with weighted logistic regression analysis. Findings: cVDPV caused by serotype 2 poliovirus was the predominant strain (95%) of 1818 total human cVDPV cases reported. Of 40 countries reporting cVDPV cases or isolates, 22 (55%) had polio vaccination coverages below 80%. Low vaccination coverage (Adjusted OR = 83·41, 95% CI: [5·01, 1387·71], p = 0·0020) was found to be associated with increased odds of reporting cVDPV after adjusting for confounding effects of GDP per capita, female adult literacy rates, maternal mortality rate, and Global Peace Index. Interpretation: Our findings reinforce the importance of maintaining high levels of vaccination, as risk of re-emergence rises when immunity wanes. Interventions to increase vaccination and standards of living in developing countries, coupled with robust surveillance are required if humanity hopes to eradicate polio in the near future. Funding: This research was supported by the MRFF 2021 Frontier Health and Medical Research Grant (ID RFRHPI000280), Department of Health, the Australian Government.
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