Evidence map›Paper›PMID 35784326›Full record

ReviewFrontiers in immunology2022

Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future.

José Saura-Esteller, Milon de Jong, Lisa A King, Erik Ensing, Benjamin Winograd, Tanja D de Gruijl, Paul W H I Parren, Hans J van der Vliet

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 172 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
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  6. Review
  7. Article
  8. Article
  9. Article
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  11. Article
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  15. Adoptive T-cell therapies in the clinic.Bioengineering & translational medicine · 2026
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

José Saura-EstellerDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Milon de JongDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Lisa A KingDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Erik EnsingLAVA Therapeutics, Utrecht, Netherlands.
Benjamin WinogradLAVA Therapeutics, Philadelphia, PA, United States.
Tanja D de GruijlDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Paul W H I ParrenLAVA Therapeutics, Utrecht, Netherlands.
Hans J van der VlietDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Amsterdam University Medical Centers · NLLava Therapeutics (Netherlands) · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen presentation, which makes them a highly promising effector cell compartment for cancer immunotherapy. Novel γδ T-cell-based immunotherapies, primarily focusing on the two major γδ T-cell subtypes that infiltrate tumors (

Indexed as

Intraepithelial LymphocytesNeoplasmsHumansImmunotherapyReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, gamma-deltaadoptive cell transferaminobisphosphonatesbispecific t-cell engagercancerchimeric antigen receptorgamma delta T-cellimmunotherapyphosphoantigens

Identifiers

PMID35784326
PMCPMC9245381
OpenAlexW4282966989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.