Evidence map›Paper›PMID 35783839›Full record

ArticleFrontiers in cardiovascular medicine2022

Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort.

Romy de Laat-Kremers, Augusto Di Castelnuovo, Lisa van der Vorm, Simona Costanzo, Marisa Ninivaggi, Chiara Cerletti, Dana Huskens, Amalia De Curtis, Alessandro Gialluisi, Cuicui Bai and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Obesity-Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Clot or Not? Reviewing the Reciprocal Regulation Between Lipids and Blood Clotting.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Romy de Laat-KremersDepartment of Data Analysis and Artificial Intelligence, Synapse Research Institute, Maastricht, Netherlands.
Augusto Di CastelnuovoMediterranea Cardiocentro, Naples, Italy.
Lisa van der VormDepartment of Functional Coagulation, Synapse Research Institute, Maastricht, Netherlands.
Simona CostanzoDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Marisa NinivaggiDepartment of Functional Coagulation, Synapse Research Institute, Maastricht, Netherlands.
Chiara CerlettiDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Dana HuskensDepartment of Functional Coagulation, Synapse Research Institute, Maastricht, Netherlands.
Amalia De CurtisDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Alessandro GialluisiDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Cuicui BaiDepartment of Functional Coagulation, Synapse Research Institute, Maastricht, Netherlands.
Giovanni de GaetanoDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Dongmei YinDepartment of Functional Coagulation, Synapse Research Institute, Maastricht, Netherlands.
Maria Benedetta DonatiDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Bas de LaatDepartment of Data Analysis and Artificial Intelligence, Synapse Research Institute, Maastricht, Netherlands.
Licia IacovielloDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
Moli-sani Investigators
Synapse (Netherlands) · NLIstituto Neurologico Mediterraneo · ITClinica Mediterranea · ITUniversity of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coagulation system can be assessed by the thrombin generation (TG) assay, and increased TG peak height, endogenous thrombin potential (ETP), and velocity index are associated with an increased risk of thrombosis. Obesity had been reported to increase TG and is associated with dyslipidemia, which also predisposes to atherosclerotic cardiovascular disease (CVD). However, the effect of the blood lipid profile on TG has not been studied extensively. To gain more insight into the associations of TG, body mass index (BMI) and lipid profile, we studied TG in relation to these parameters in a large Italian population cohort, the Moli-sani study (

Indexed as

BMIlipidsMoli-sanithrombinthrombin generation

Identifiers

PMID35783839
PMCPMC9243635
OpenAlexW4283008724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.