Evidence map›Paper›PMID 35783637›Full record

ArticleFrontiers in medicine2022

Hepatic Arterial Infusion Chemotherapy With Folfirinox or Oxaliplatin Alone in Metastatic Colorectal Cancer.

Violaine Randrian, Simon Pernot, Baptiste Sionneau, Denis Smith, Annie Lim, Yann Touchefeu, Claire Gallois, Anthony Turpin, Sahir Javed, Rosine Guimbaud and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Violaine RandrianDepartment of Hepato-Gastro-Enterology, CHU Poitiers, Poitiers, France.
Simon PernotDepartment of Medical Oncology, Institut Bergonié, Bordeaux, France.
Baptiste SionneauMedical Oncology, Bordeaux University Hospital, Bordeaux, France.
Denis SmithMedical Oncology, Bordeaux University Hospital, Bordeaux, France.
Annie LimDepartment of Gastroenterology, Clinique Santé Atlantique, Saint-Herblain, France.
Yann TouchefeuDepartment of Hepatogastroenterology, Digestive Oncology, Nantes University Hospital, Nantes, France.
Claire GalloisDepartment of Gastrointestinal Oncology, Université de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Anthony TurpinDepartment of Oncology, CHU Lille, Lille, France.
Sahir JavedDepartment of Oncology, CHU Lille, Lille, France.
Rosine GuimbaudDepartment of Digestive Oncology, IUCT-Rangueil, CHU Toulouse, Toulouse, France.
Pascale RiveraDepartment of Digestive Oncology, IUCT-Rangueil, CHU Toulouse, Toulouse, France.
Mehdi KarouiDepartment of Surgical Oncology, Université de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Edouard AuclinMethodology and Quality of Life Unit in Oncology, University Hospital of Besançon, Bourgogne Franche-Comté University, INSERM, EFS BFC, UMR 1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Besançon, France.
Julien TaiebDepartment of Gastrointestinal Oncology, Université de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Bordeaux Population Health · FRCentre Hospitalier Universitaire de Lille · FRHôpital Européen Georges-Pompidou · FRHôpital Rangueil · FRCentre Hospitalier Universitaire de Poitiers · FRInserm · FRInstitut Bergonié · FRInstitut Génétique Nantes Atlantique · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatic arterial infusion (HAI) of chemotherapy is an option for the treatment of patients with liver metastases from colorectal cancer (LMCRC). Though HAI with oxaliplatin (HAI-Ox) is generally used, intravenous (IV) 5-fluoro-uracil (5FU)-oxaliplatin-irinotecan HAI (HAI-Folfirinox) is feasible and leads to curative-intent surgery in 30% of pretreated patients. We compared the efficacy and safety of HAI-Ox and HAI-Folfirinox. Methods: Patients who underwent HAI chemotherapy for LMCRC were retrospectively included from 2008 to 2019 from six French expert centers. Results: Data were collected from 273 previously treated patients with LMCRC. Patients received HAI-Folfirinox ( Conclusion: Hepatic arterial infusion results in high response rates, secondary resections, and long survival in pretreated patients with LMCRC.

Indexed as

cancer treatmentcolorectal cancerhepatic arterial infusionliver metastasessurgery

Identifiers

PMID35783637
PMCPMC9243466
OpenAlexW4283009220

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.