ArticleSports medicine and health science2021
The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration.
Article in Sports medicine and health science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Muscle Ultrasound Echo Intensity Detects Insulin Resistance Before Changes in HbAJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Intramuscular collagen accumulation in different types of skeletal muscle fibers in middle-aged male rats.Journal of toxicologic pathology · 2026Article
- Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity.BMC genomics · 2025Article
- Muscle Ultrasound: A Novel Noninvasive Tool for Early Detection of Developing Insulin Resistance and Lower Muscle Mass in Obesity.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Maintaining the balance: the critical role of plasmin activity in orthopedic surgery injury response.Journal of thrombosis and haemostasis : JTH · 2023Review
- Effects of Obesity in Old Age on the Basement Membrane of Skeletal Muscle in Mice.International journal of molecular sciences · 2023Article
- Evaluation of Geriatric Sarcopenia and Nutrition in the Case of Cachexia before Exitus: An Observational Study for Health Professionals.Geriatrics (Basel, Switzerland) · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diet-induced obesity has previously been shown to occur with the concomitant rise in the expression of proinflammatory cytokines and increases in collagen deposition. While it has been known that the regenerative process of skeletal muscle is altered in obese mice following an acute muscle injury, we sought to examine differences in the expression of various markers of extracellular matrix remodeling and repair. Our laboratory has previously reported an impaired inflammatory and protein synthetic signaling in these mice that may contribute negatively to the muscle regenerative process. To expand upon this previous investigation, tissues from these animals underwent further analysis to determine the extent of changes to the regenerative response within the extracellular matrix, including transcriptional changes in Collagen I, Collagen III, and Fibronectin. Here, we show that the expression of Collagen III:I is significantly increased at 3-days post-injury in obese injured animals compared to lean injured animals (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.