ArticleFrontiers in pediatrics2022
Subclinical Left Ventricular Dysfunction in Children and Adolescence With Thalassemia Intermedia.
Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
- Safety of erythrocyte transfusion over a short period in pediatric patients assessed using cardiac deformation imaging.European journal of pediatrics · 2024Article
- Aromatase Inhibitors May Increase the Risk of Cardiometabolic Complications in Adolescent Boys.Pediatric cardiology · 2024Review
- Subclinical cardiac dysfunction in transfusion-dependent beta-thalassemia children, an experience from central India: A comparative cross-sectional study.Annals of pediatric cardiologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Background: Cardiac complications are important causes of morbidity in patients with thalassemia intermedia (TI). We aimed to assess left ventricular (LV) function, using new tissue Doppler imaging (TDI) indices, in order to diagnose early ventricular impairment in asymptomatic children and adolescence with the TI. Materials and Methods: We investigated possible differences in echocardiographic systolic and diastolic parameters between a population of 28 asymptomatic patients (mean age, 13.6 ± 5.7 years) and 35 age-matched healthy control members. All of them underwent 2-D, pulsed Doppler, and tissue Doppler echocardiographic studies for the assessment of the LV mass, Trans-mitral velocities, mitral annular systolic and diastolic velocities, myocardial performance index (MPI), and myocardial acceleration during isovolumic contraction (IVA). The cardiac iron load was estimated by magnetic resonance imaging T2*. Results: Left ventricular hypertrophy (LVH) was found in 13 (46.4%) patients. We found significantly reduced TDI-derived peak systolic myocardial velocity (s') in patients, whereas no significant difference was identified between the patients and control group members when the IVA was compared. The ratio of peak mitral inflow velocity to annular early diastolic velocity (E/e') of the mitral valve as an index of the diastolic function was significantly higher in patients (9 ± 1 vs. 6 ± 1, Conclusion: Subtle LV systolic and diastolic dysfunction develops early in young patients with the TI who have normal cardiac iron concentration. Moreover, LV remodeling as a main cardiac adaptive response plays a principal role in developing myocardial impairment.
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