Evidence map›Paper›PMID 35783258›Full record

ArticleFrontiers in genetics2022

Bursts of Genomic Instability Potentiate Phenotypic and Genomic Diversification in

Lydia R Heasley, Juan Lucas Argueso

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Comparative functional genomics ofMicrobiology spectrum · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lydia R HeasleyDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
Juan Lucas ArguesoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
Colorado State University · US

Funding

MinION long-read DNA sequencer system for the analysis of structural genomic variation in yeastR35GM119788 · NIGMS · COLORADO STATE UNIVERSITY · PI ARGUESO, JUAN LUCAS · 2016 to 2025
$3.7M
Properties and mechanisms of punctuated genome instabilityR00GM134193 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI HEASLEY, LYDIA RENE · 2022 to 2024
$747k
Properties and Mechanisms of Punctuated Genome InstabilityK99GM134193 · NIGMS · COLORADO STATE UNIVERSITY · PI HEASLEY, LYDIA RENE · 2020 to 2022
$233k
NIGMS NIH HHS K99 GM134193NIGMS NIH HHS R00 GM134193NIGMS NIH HHS R35 GM119788
6 · The paper itself

Abstract

How microbial cells leverage their phenotypic potential to survive in a changing environment is a complex biological problem, with important implications for pathogenesis and species evolution. Stochastic phenotype switching, a particularly fascinating adaptive approach observed in numerous species across the tree of life, introduces phenotypic diversity into a population through mechanisms which have remained difficult to define. Here we describe our investigations into the mechanistic basis of colony morphology phenotype switching which occurs in populations of a pathogenic isolate of

Indexed as

aneuploidygenome evolutiongenomic instabilityphenotypic plasticitypunctuated equilibrium

Identifiers

PMID35783258
PMCPMC9247159
OpenAlexW4283008412

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.