ArticleFrontiers in behavioral neuroscience2022
Jugular Vein Catheter Design and Cocaine Self-Administration Using Mice: A Comprehensive Method.
Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Reln Haploinsufficiency Enhances Fentanyl-Induced Locomotion and Dorsal Striatal Activity Without Affecting Opioid Reinforcement and Relapse-Like Behavior.Genes, brain, and behavior · 2026Article
- Mitragynine reduces methamphetamine self-administration in rats without disrupting food-maintained responding.Psychopharmacology · 2026Article
- Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activity without affecting opioid reinforcement and relapse-like behavior.bioRxiv : the preprint server for biology · 2026Article
- Intranasal cocaine self-administration in male mice.Nature communications · 2025Article
- Cocaine-Induced Microglial Impairment and Its Rehabilitation by PLX-PAD Cell Therapy.International journal of molecular sciences · 2024Article
- Head-mounted central venous access during optical recordings and manipulations of neural activity in mice.Nature protocols · 2024Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Intravenous self-administration (IVSA) is a behavioral method of voluntary drug intake in animal models which is used to study the reinforcing effects of drugs of abuse. It is considered to have greater face validity in the study of substance use and abuse than other assays, and thus, allows for valuable insight into the neurobiological basis of addiction, and the development of substance abuse disorders. The technique typically involves surgically inserting a catheter into the jugular vein, which enables the infusion of drug solution after the performance of a desired operant behavior. Two nose- poke ports or levers are offered as manipulanda and are randomly assigned as active (reinforced) or inactive (non-reinforced) to allow for the examination of discrimination in the assessment of learning. Here, we describe our methodological approach to this assay in a mouse model, including construction and surgical implantation of a jugular vein catheter, set up of operant chambers, and considerations during each phase of the operant task.
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Registered trials
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