ArticleBiomarkers in neuropsychiatry2021
A pilot spectroscopy study of adversity in adolescents.
Article in Biomarkers in neuropsychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Neurophysiological markers of GABAergic and glutamatergic function associated with childhood adversity in adolescent depression: An exploratory transcranial magnetic stimulation study.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Cross-sectional study of retrospective self-reported childhood emotional neglect and inhibitory neurometabolite levels in the pregenual anterior cingulate cortex in adult humans.Neurobiology of stress · 2023Article
- Signatures of exposure to childhood trauma in young adults in the structure and neurochemistry of the superior temporal gyrus.Journal of psychopharmacology (Oxford, England) · 2023Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
Background: Childhood adversity is a global health problem affecting 25-50% of children worldwide. Few prior studies have examined the underlying neurochemistry of adversity in adolescents. This cross-sectional study examined spectroscopic markers of trauma in a cohort of adolescents with major depressive disorder (MDD) and healthy controls. We hypothesized that historical adversity would have a negative relationship with spectroscopic measures of glutamate metabolites in anterior cingulate cortex. Methods: Adolescent participants (aged 13-21) underwent a semi-structured diagnostic interview and clinical assessment, which included the self-report Childhood Trauma Questionnaire (CTQ), a 28-item assessment of childhood adversity. Proton magnetic resonance spectroscopy ( Results: Thirty-nine participants (17 healthy controls, 22 depressed participants) underwent Conclusions: Our findings suggest that childhood adversity may impact brain neurochemical profiles. Further longitudinal studies should examine neurochemical correlates of childhood adversity throughout development and in populations with other psychiatric disorders.
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