Evidence map›Paper›PMID 35783152›Full record

ArticleJournal of oncology2022

Identification of ABCA5 among ATP-Binding Cassette Transporter Family as a New Biomarker for Colorectal Cancer.

Peilong Bu, Yafei Xiao, Shaowen Hu, Xiaowei Jiang, Cong Tan, Mengyuan Qiu, Wanting Huang, Mengmeng Li, Quanying Li, Changjiang Qin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Peilong BuDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China.ORCID https://orcid.org/0000-0001-8971-0225
Yafei XiaoDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China.ORCID https://orcid.org/0000-0002-7704-8622
Shaowen HuDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China.ORCID https://orcid.org/0000-0003-2421-9501
Xiaowei JiangDepartment of Pediatric Orthopedics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.ORCID https://orcid.org/0000-0002-9622-4409
Cong TanInstitute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.ORCID https://orcid.org/0000-0002-7985-6682
Mengyuan QiuInstitute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.ORCID https://orcid.org/0000-0003-3730-4457
Wanting HuangInstitute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.ORCID https://orcid.org/0000-0002-2283-4351
Mengmeng LiDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China.ORCID https://orcid.org/0000-0002-8623-331X
Quanying LiDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China.ORCID https://orcid.org/0000-0001-6447-4289
Changjiang QinDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China.ORCID https://orcid.org/0000-0003-4295-4964
Henan University Huaihe Hospital and Huaihe Clinical Institute · CNHenan University · CNThird Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The increasing incidence and mortality of colorectal cancer (CRC) urgently requires updated biomarkers. The ABC transporter family is a widespread family of membrane-bound proteins involved in the transportation of substrates associated with ATP hydrolysis, including metabolites, amino acids, peptides and proteins, sterols and lipids, organic and inorganic ions, sugars, metals, and drugs. They play an important role in the maintenance of homeostasis in the body. Purpose: This study aims to search for new markers in the ABC transporter gene family for diagnostic and prognostic purposes through data mining of The Cancer Genome Atlas (TCGA) and GEO (Gene Expression Omnibus) datasets. Methods: A total of 980 samples, including 684 CRC patients and 296 controls from five different datasets, were included for analysis. The construction of the PPI (protein-protein interaction) network and pathway analysis were performed in STRING database and DAVID (database for annotation, visualization, and integrated discovery), respectively. In addition, GSEA (gene set enrichment analysis) and WGCNA (weighted gene co-expression network analysis) were also used for functional analysis. Results: After several rounds of screening and validation, only the Conclusions: The results demonstrated that

Identifiers

PMID35783152
PMCPMC9242773
OpenAlexW4283323866

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.