Evidence map›Paper›PMID 35783072›Full record

ArticleJAMIA open2022

Enhancing research data infrastructure to address the opioid epidemic: the Opioid Overdose Network (O2-Net).

Leslie A Lenert, Vivienne Zhu, Lindsey Jennings, Jenna L McCauley, Jihad S Obeid, Ralph Ward, Saeed Hassanpour, Lisa A Marsch, Michael Hogarth, Perry Shipman and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in JAMIA open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Leslie A LenertBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Vivienne ZhuBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Lindsey JenningsDepartment of Emergency Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Jenna L McCauleyDepartment of Psychiatry, Medical University of South Carolina, Charleston, South Carolina, USA.
Jihad S ObeidBiomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID https://orcid.org/0000-0002-7193-7779
Ralph WardDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID https://orcid.org/0000-0001-6193-2838
Saeed HassanpourBiomedical Data Science Department, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0001-9460-6414
Lisa A MarschCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.
Michael HogarthDepartment of Biomedical Informatics, University of California San Diego, San Diego, California, USA.
Perry ShipmanAltman Clinical and Translational Research Institute, University of California San Diego, San Diego, California, USA.
Daniel R HarrisInstitute for Biomedical Informatics, University of Kentucky, Lexington, Kentucky, USA.
Jeffery C TalbertInstitute for Biomedical Informatics, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0002-4304-5167
Medical University of South Carolina · USDartmouth College · USUniversity of California San Diego · USUniversity of Kentucky · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Treatment Development & Evaluation CoreP30DA029926 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2011 to 2026
$21.5M
SYNERGY: The Dartmouth Center for clinical and Translational ScienceUL1TR001086 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$18.3M
Enhancing Infrastructure for Clinical and Translational Research to Address the Opioid EpidemicU01TR002628 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LENERT, LESLIE A. · 2019 to 2023
$3.7M
NCATS NIH HHS U01 TR002628NCATS NIH HHS UL1 TR001086NCATS NIH HHS UL1 TR001442NCATS NIH HHS UL1 TR001450NCATS NIH HHS UL1 TR001998NIDA NIH HHS P30 DA029926
6 · The paper itself

Abstract

Opioid Overdose Network is an effort to generalize and adapt an existing research data network, the Accrual to Clinical Trials (ACT) Network, to support design of trials for survivors of opioid overdoses presenting to emergency departments (ED). Four institutions (Medical University of South Carolina [MUSC], Dartmouth Medical School [DMS], University of Kentucky [UK], and University of California San Diego [UCSD]) worked to adapt the ACT network. The approach that was taken to enhance the ACT network focused on 4 activities: cloning and extending the ACT infrastructure, developing an e-phenotype and corresponding registry, developing portable natural language processing tools to enhance data capture, and developing automated documentation templates to enhance extended data capture. Overall, initial results suggest that tailoring of existing multipurpose federated research networks to specific tasks is feasible; however, substantial efforts are required for coordination of the subnetwork and development of new tools for extension of available data. The initial output of the project was a new approach to decision support for the prescription of naloxone for home use in the ED, which is under further study within the network.

Indexed as

clinical trialselectronic health records systemse-phenotypenatural language processingopioid abuseopioid overdose

Identifiers

PMID35783072
PMCPMC9243402
OpenAlexW4283724687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.