ArticleJournal of tissue engineering
Tissue-engineered composite tracheal grafts create mechanically stable and biocompatible airway replacements.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Successful Early Neovascularization in Composite Tracheal Grafts.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2023Trial
- Endothelial Hydrogels Improve Microvascular Regeneration and Perfusion in Tracheal Scaffolds.The Laryngoscope · 2026Article
- Study of the potential protective efficacy of lactoferrin on indomethacin-induced gastric fundic mucosal injury in rats.Journal of molecular histology · 2026Article
- Tracheal Regeneration: Recent Progress in the Application of Stem Cells in Tracheal Bioengineering.International journal of molecular sciences · 2026Review
- Multiplexed self-adaptable Janus hydrogels rescue epithelial malfunction to promote complete trachea repair.Nature communications · 2025Article
- Assessing the Impact of Partial Decellularization on Tracheal Chondrocytes and Extracellular Matrix in Airway Reconstruction.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Cartilage Tissue Engineering in Multilayer Tissue Regeneration.Annals of biomedical engineering · 2025Review
- Proteomic Analysis of Surgery-induced Stress Post-Tracheal Transplantation Highlights Changes in Matrisome.The Laryngoscope · 2024Article
- Tissue-engineered tracheal implants: Advancements, challenges, and clinical considerations.Bioengineering & translational medicine · 2024Review
- Recent Advances in the Application of 3D-Printing Bioinks Based on Decellularized Extracellular Matrix in Tissue Engineering.ACS omega · 2024Review
- Assessing the Biocompatibility and Regeneration of Electrospun-Nanofiber Composite Tracheal Grafts.The Laryngoscope · 2024Article
- Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication.Medicina (Kaunas, Lithuania) · 2023Review
- Partial decellularization eliminates immunogenicity in tracheal allografts.Bioengineering & translational medicine · 2023Article
- Regeneration of tracheal neotissue in partially decellularized scaffolds.NPJ Regenerative medicine · 2023Article
- Current Status and Future Outlook of Additive Manufacturing Technologies for the Reconstruction of the Trachea.Journal of functional biomaterials · 2023Review
- Article
- Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering.Frontiers in bioengineering and biotechnology · 2023Article
- Multifunctional Medical Grade Resin with Enhanced Mechanical and Antibacterial Properties: The Effect of Copper Nano-Inclusions in Vat Polymerization (VPP) Additive Manufacturing.Journal of functional biomaterials · 2022Article
- Advanced lung organoids for respiratory system and pulmonary disease modeling.Journal of tissue engineeringReview
- Evaluation Strategies for Tissue-engineered Tracheas: FromIn vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
We tested composite tracheal grafts (CTG) composed of a partially decellularized tracheal graft (PDTG) combined with a 3-dimensional (3D)-printed airway splint for use in long-segment airway reconstruction. CTG is designed to recapitulate the 3D extracellular matrix of the trachea with stable mechanical properties imparted from the extraluminal airway splint. We performed segmental orthotopic tracheal replacement in a mouse microsurgical model. MicroCT was used to measure graft patency. Tracheal neotissue formation was quantified histologically. Airflow dynamic properties were analyzed using computational fluid dynamics. We found that CTG are easily implanted and did not result in vascular erosion, tracheal injury, or inflammation. Graft epithelialization and endothelialization were comparable with CTG to control. Tracheal collapse was absent with CTG. Composite tracheal scaffolds combine biocompatible synthetic support with PDTG, supporting the regeneration of host epithelium while maintaining graft structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.