Evidence map›Paper›PMID 35782947›Full record

ReviewFrontiers in nutrition2022

Effects of Dietary Nutrients on Fatty Liver Disease Associated With Metabolic Dysfunction (MAFLD): Based on the Intestinal-Hepatic Axis.

Nan Yao, Yixue Yang, Xiaotong Li, Yuxiang Wang, Ruirui Guo, Xuhan Wang, Jing Li, Zechun Xie, Bo Li, Weiwei Cui

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  13. Machine learning uncovers manganese as a key nutrient associated with reduced risk of steatotic liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2024
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  15. Current developments in nutrition · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nan YaoDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Yixue YangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Xiaotong LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Yuxiang WangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Ruirui GuoDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Xuhan WangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Jing LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Zechun XieDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Bo LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Weiwei CuiDepartment of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) has recently become the most common liver disease with a global prevalence of over 25% and is expected to increase. Recently, experts have reached a consensus that "fatty liver disease associated with metabolic dysfunction or MAFLD" may be a more appropriate and inclusive definition than NAFLD. Like the former name NAFLD, MAFLD, as a manifestation of multiple system metabolic disorders involving the liver, has certain heterogeneity in its pathogenesis, clinical manifestations, pathological changes and natural outcomes. We found that there is a delicate dynamic balance among intestinal microflora, metabolites and host immune system to maintain a healthy intestinal environment and host health. On the contrary, this imbalance is related to diseases such as MAFLD. However, there are no clear studies on how dietary nutrients affect the intestinal environment and participate in the pathogenesis of MAFLD. This review summarizes the interactions among dietary nutrients, intestinal microbiota and MAFLD in an attempt to provide evidence for the use of dietary supplements to regulate liver function in patients with MAFLD. These dietary nutrients influence the development and progression of MAFLD mainly through the hepatic-intestinal axis by altering dietary energy absorption, regulating bile acid metabolism, changing intestinal permeability and producing ethanol. Meanwhile, the nutrients have the ability to combat MAFLD in terms of enriching abundance of intestinal microbiota, reducing

Indexed as

dietary nutrientsfatty liver disease associated with metabolic dysfunctionintestinal-hepatic axisMAFLDNAFLDnon-alcoholic fatty liver disease

Identifiers

PMID35782947
PMCPMC9247350
OpenAlexW4283076810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.