ArticleSynthesis2019
Advancements in Visible-Light-Enabled Radical C(sp)2-H Alkylation of (Hetero)arenes.
Article in Synthesis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Review
- Efficient Approaches to Six-Membered Polyazacyclic Compounds-Part 3: C-H Functionalization of Heterocycles.Molecules (Basel, Switzerland) · 2026Review
- Discovery and Development of the Enantioselective Minisci Reaction.Accounts of chemical research · 2023Article
- Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.Journal of the American Chemical Society · 2023Article
- Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.Research square · 2023Article
- Pyridine C(spBeilstein journal of organic chemistry · 2023Review
- Dual role of benzophenone enables a fast and scalable C-4 selective alkylation of pyridines in flow.Chemical science · 2022Article
- Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols.Angewandte Chemie (International ed. in English) · 2022Article
- General electrochemical Minisci alkylation ofChemical science · 2022Article
- Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis.Angewandte Chemie (International ed. in English) · 2021Article
- Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides.Journal of the American Chemical Society · 2021Article
- Radical-based functionalization-oriented construction: rapid assembly of azaarene-substituted highly functionalized pyrroles.Chemical science · 2021Article
- Visible-Light Photocatalysis as an Enabling Technology for Drug Discovery: A Paradigm Shift for Chemical Reactivity.ACS medicinal chemistry letters · 2020Article
- Generation of Alkyl Radicals: From the Tyranny of Tin to the Photon Democracy.Chemical reviews · 2020Article
- Photoredox-Mediated Net-Neutral Radical/Polar Crossover Reactions.Israel journal of chemistry · 2020Article
- Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines.Journal of the American Chemical Society · 2019Article
- Site-selective remote C(spNature communications · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The Minisci reaction, which encompasses the radical C-H alkylation of heteroarenes, has undergone revolutionary development in recent years. The application of photoredox catalysis for alkyl radical generation has given rise to a multitude of methods that feature enhanced functional group tolerance, generality, and operational simplicity. The intent of this short review is to bring readers up to date on this rapidly expanding field. Specifically, we will highlight key examples of visible light-driven Minisci alkylation strategies that represent key advancements in this area of research. The scope and limitation of these transformations will be discussed, with a focus on examining the underlying pathways for alkyl radical generation. Our goal is to make this short review a stepping stone for further synthetic research development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.