Evidence map›Paper›PMID 35782784›Full record

ArticleBiochemistry and biophysics reports2022

Complex formation of potassium salt of highly fatty acid with hemagglutinin protein in influenza virus via exothermic interaction.

Takayoshi Kawahara, Megumi Sakou, Yukie Fumotogawa, Satoshi Kanazawa, Takemasa Sakaguchi, Isamu Akiba

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Takayoshi KawaharaResearch and Development Department, Shabondama Soap Co., Ltd., 2-23-1 Minamifutashima, Wakamatsu, Kitakyushu, 808-0195, Japan.
Megumi SakouDepartment of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, 808-0135, Japan.
Yukie FumotogawaDepartment of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, 808-0135, Japan.
Satoshi KanazawaDepartment of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, 808-0135, Japan.
Takemasa SakaguchiDepartment of Virology, Institute of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Isamu AkibaDepartment of Chemistry and Biochemistry, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, 808-0135, Japan.
The University of Kitakyushu · JPHiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our previous study, we found highly fatty acid salts, which are a skin-friendly soaps, had a high ability to inactivate the influenza virus. In order to elucidate the mechanism of inactivation of influenza virus, we investigated interactions and complex formation of potassium tetradecanoate (C14K) as a highly fatty acid salt with a virus particle (VP) derived from avian influenza virus by using isothermal titration calorimetry (ITC) and small-angle X-ray scattering (SAXS). ITC showed C14K attractively interacted with hemagglutinin protein (HA) which exists in the envelop of VP. SAXS analyses revealed C14K formed highly ordered complex with HA through the attractive interaction. Since the HA is responsible for cell entry events, inactivation of influenza viruses by highly fatty acid salts are derived owing to HA inhibition of influenza viruses through the complex formation. Time-resolved SAXS measurements elucidated the complex formation was completed within 40 s after mixing aqueous solutions of C14K and VP. This result strongly suggests that hand-washing with a highly fatty acid salts is an effective measure to prevent infection with influenza virus without causing rough hands.

Indexed as

Hemagglutinin proteinInfluenza virusIsothermal titration calorimetryNatural soapSmall-angle X-ray scattering

Identifiers

PMID35782784
PMCPMC9240363
OpenAlexW4283517147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.