Evidence map›Paper›PMID 35782649›Full record

ArticleToxicology research2022

Metabolomics mapping changed after olanzapine therapy in drug-naive schizophrenia patients-the significant impact of gene polymorphisms.

Bensu Karahalil, Aylin Elkama, Mehmet Ak, Emirhan Nemutlu

Open access · bronzeAbstract read
In one paragraph

Article in Toxicology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Are changes in olanzapine-induced liver enzyme levels associated withArhiv za higijenu rada i toksikologiju · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Bensu KarahalilDepartment of Toxicology, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.ORCID https://orcid.org/0000-0003-1625-6337
Aylin ElkamaDepartment of Toxicology, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.
Mehmet AkDepartment of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya 42080, Turkey.
Emirhan NemutluDepartment of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara 06230, Turkey.
Gazi University · TRHacettepe University · TRNecmettin Erbakan University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress may contribute to the development of schizophrenia and antipsychotics used in schizophrenia treatment may also cause oxidative stress. Gene polymorphisms on antioxidant and repair enzymes are responsible for individual variations and may change the efficacy of olanzapine treatment among schizophrenia patients. In our study, we assessed oxidative stress-related metabolite changes due to genetic polymorphisms on first diagnosed-schizophrenia patients treated with olanzapine. Blood samples (

Indexed as

gene polymorphismglutathione-S-transferasesindividual susceptibilitymetabolomicsolanzapine

Identifiers

PMID35782649
PMCPMC9244978
OpenAlexW4281753710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.