Evidence map›Paper›PMID 35782608›Full record

ArticleMolecular genetics and metabolism reports2022

Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells.

Mohammad Arif Hossain, Minami Hasegawa-Ogawa, Yoko Manome, Miki Igarashi, Chen Wu, Ken Suzuki, Junko Igarashi, Takeo Iwamoto, Hirotaka James Okano, Yoshikatsu Eto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Generation of Donor-Specific iPSC for Modelling Lysosomal Storage Disorders.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Article
  3. Zebra-Sphinx: Modeling Sphingolipidoses in Zebrafish.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mohammad Arif HossainAdvanced Clinical Research Center, Institute of Neurological Disorders, Kawasaki, Kanagawa, Japan.
Minami Hasegawa-OgawaDivision of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Yoko ManomeDivision of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Miki IgarashiAdvanced Clinical Research Center, Institute of Neurological Disorders, Kawasaki, Kanagawa, Japan.
Chen WuAdvanced Clinical Research Center, Institute of Neurological Disorders, Kawasaki, Kanagawa, Japan.
Ken SuzukiAdvanced Clinical Research Center, Institute of Neurological Disorders, Kawasaki, Kanagawa, Japan.
Junko IgarashiAdvanced Clinical Research Center, Institute of Neurological Disorders, Kawasaki, Kanagawa, Japan.
Takeo IwamotoAdvanced Clinical Research Center, Institute of Neurological Disorders, Kawasaki, Kanagawa, Japan.
Hirotaka James OkanoDivision of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Yoshikatsu EtoAdvanced Clinical Research Center, Institute of Neurological Disorders, Kawasaki, Kanagawa, Japan.
Jikei University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathological consequences leading to primary storage, autophagy impairment, impaired mitochondrial dynamics, and endoplasmic reticulum (ER) stress on neural cell dysfunction and apoptosis in metachromatic leukodystrophy (MLD) have been poorly elucidated. In the present study, we generated 2 cell lines of patient-specific-induced pluripotent stem cells (iPSCs) and modeled the progression of pathological events during the differentiation of iPSCs to motor neuron progenitors (MNPs) and mature motor neurons (MNs). The iPS cells were generated from two late-infantile MLD patient-derived skin fibroblasts using electroporation or the Sendai virus. Olig2

Indexed as

ApoptosisER stressMitophagyMotor neuron progenitorsMotor neurons

Identifiers

PMID35782608
PMCPMC9248224
OpenAlexW4213345748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.