Evidence map›Paper›PMID 35782606›Full record

ArticleMolecular genetics and metabolism reports2022

Increased atherosclerosis in a mouse model of glycogen storage disease type 1a.

Anouk M La Rose, Anouk G Groenen, Benedek Halmos, Venetia Bazioti, Martijn G S Rutten, Kishore A Krishnamurthy, Mirjam H Koster, Niels J Kloosterhuis, Marieke Smit, Rick Havinga and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Anouk M La RoseDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Anouk G GroenenDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Benedek HalmosDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Venetia BaziotiDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Martijn G S RuttenDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Kishore A KrishnamurthyDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Mirjam H KosterDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Niels J KloosterhuisDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Marieke SmitDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Rick HavingaDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Gilles MithieuxUniversité Claude Bernard Lyon 1, Université de Lyon, INSERM UMR-S1213, Lyon, France.
Fabienne RajasUniversité Claude Bernard Lyon 1, Université de Lyon, INSERM UMR-S1213, Lyon, France.
Folkert KuipersDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Maaike H OosterveerDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Marit WesterterpDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
University of Groningen · NLUniversity Medical Center Groningen · NLInserm · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

Indexed as

AtherosclerosisG6PC1, Glucose-6-phosphatase enzymeG6P, Glucose-6-phosphateGlycogen storage disease type 1aGSD Ia, Glycogen storage disease type 1aHDL, High-density lipoproteinHyperlipidemiaLdlr−/−, LDL receptor deficientPUFA, Poly-unsaturated FASFA, Saturated fatty acidsTG, TriglyceridesVLDL, Very-low-density lipoproteinWTD, Western-type diet

Identifiers

PMID35782606
PMCPMC9248218
OpenAlexW4224252538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.