Evidence map›Paper›PMID 35782531›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Stimulation of CGRP-expressing neurons in the medial cerebellar nucleus induces light and touch sensitivity in mice.

Mengya Wang, William C Castonguay, Thomas L Duong, Michael W Huebner, Harold C Flinn, Agatha M Greenway, Andrew F Russo, Levi P Sowers

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. PACAP versus CGRP in migraine: From mouse models to clinical translation.Cephalalgia : an international journal of headache · 2025
    Review
  2. Article
  3. Brain circuits for retching-like behavior.National science review · 2024
    Article
  4. Review
  5. Review
  6. Involvement of the cerebellum in migraine.Frontiers in systems neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mengya WangDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USA.
William C CastonguayDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Thomas L DuongDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Michael W HuebnerDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Harold C FlinnDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Agatha M GreenwayDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Andrew F RussoDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Levi P SowersDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
University of Iowa · USUnited States Department of Veterans Affairs · US

Funding

Perivascular mechanisms of CGRP-induced migraine symptomsR01NS075599 · NINDS · UNIVERSITY OF IOWA · PI RUSSO, ANDREW F · 2011 to 2023
$5.0M
Investigation of cerebello-thalamic circuits for the treatment of headacheI01RX003523 · VA · IOWA CITY VA MEDICAL CENTER · PI RUSSO, ANDREW F, SOWERS, LEVI P · 2021 to 2023
–
Identification and treatment of brain regions causing post-traumatic headacheIK2RX002010 · VA · IOWA CITY VA MEDICAL CENTER · PI SOWERS, LEVI P · 2016 to 2020
–
NINDS NIH HHS R01 NS075599RRD VA I01 RX003523RRD VA IK2 RX002010
6 · The paper itself

Abstract

Calcitonin gene-related peptide (CGRP) is considered a major player in migraine pathophysiology. However, the location and mechanisms of CGRP actions in migraine are not clearly elucidated. One important question yet to be answered is: Does central CGRP signaling play a role in migraine? One candidate site is the cerebellum, which serves as a sensory and motor integration center and is activated in migraine patients. The cerebellum has the most CGRP binding sites in the central nervous system and a deep cerebellar nucleus, the medial nucleus (MN), expresses CGRP (MN

Indexed as

CerebellumCGRPCGRP, calcitonin gene-related peptideChR2, channelrhodopsin-2Light aversionMigraineMN, medial nucleusPain

Identifiers

PMID35782531
PMCPMC9240374
OpenAlexW4283320447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.