ReviewSports medicine and health science2019
Reversal of age-associated frailty by controlled physical exercise: The pre-clinical and clinical evidences.
Review in Sports medicine and health science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06975540 (Study of the Synergy Between Physical Exercise and a Nutritional Supplement for the Prevention and Treatment of Frailty), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Synergy Between Physical Exercise and a Nutritional Supplement for the Prevention and Treatment of Frailty: The ROBUSTNES Study
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effects of Different Exercise Training Types on Body Composition and Physical Performance in Older Adults with Sarcopenic Obesity: A Systematic Review and Meta-Analysis.The journal of nutrition, health & aging · 2023Pooled it
- Trial
- Trial
- A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice.Journal of cachexia, sarcopenia and muscle · 2025Article
- Nomogram model for screening the risk of frailty in older adult atrial fibrillation patients: a cross-sectional study.Frontiers in public health · 2024Article
- Validation of the questionnaire for medical checkup of old-old (QMCOO) score cutoff to diagnose frailty.BMC geriatrics · 2023Article
- Effect of the Active Aging-in-Place-Rehabilitation Nursing Program: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2023Article
- Physical Activity Levels and Psychological Well-Being during COVID-19 Lockdown among University Students and Employees.International journal of environmental research and public health · 2022Article
- Associations of multicomponent exercise and aspects of physical performance with frailty trajectory in older adults.BMC geriatrics · 2022Article
- Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers.International journal of environmental research and public health · 2021Review
- Relationship between Diet, Microbiota, and Healthy Aging.Biomedicines · 2020Review
- A structured hybrid exercise programme for pre-frail older adults in primary care: A feasibility and pilot study.Digital healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Demographic aging is one of the most serious challenges facing our society. Although we live longer, we do not live better because it is considered that approximately 16-20% of our life is spent in late-life morbidity. Older people have the greatest risk of developing frailty increasing the risk of presenting various adverse health events such as low quality of life, disability, hospitalization and even death. Frail men and women over 65 years old have lower muscle quality and muscle mass and higher percentage of body fat than non-frail people of the same age. In this review we will address the main physiological changes in the muscular and nervous system associated to aging. More specifically we will review the changes in muscle mass, quality, and strength relating them with the decrease in capillarization and muscular oxidative capacity as well as with the alterations in protein synthesis in the muscle with aging. The last section of the manuscript will be devoted to the animal models of frailty and the indexes developed to measure frailty in these models. We will finally address the importance of exercise training as an intervention to delay or even reverse frailty.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.