Evidence map›Paper›PMID 35782385›Full record

ArticleFrontiers in molecular neuroscience2022

Molecular Determinants of Mechanical Itch Sensitization in Chronic Itch.

Hankyu Lee, Robert D Graham, Diana Melikyan, Brennan Smith, Ehsan Mirzakhalili, Scott F Lempka, Bo Duan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Frontiers in molecular neuroscience · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hankyu LeeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Robert D GrahamDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Diana MelikyanDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Brennan SmithDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Ehsan MirzakhaliliDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Scott F LempkaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Bo DuanDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · USBioSurfaces (United States) · US

Funding

BIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8M
TRAINING PROGRAM IN CELL AND MOLECULAR DERMATOLOGYT32AR007197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES TILFORD ELDER, Sunny Y Wong · 1986 to 2026
$4.2M
Dissecting neural circuits for mechanical itchR01NS109170 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO · 2019 to 2023
$2.2M
NIAMS NIH HHS T32 AR007197NIDA NIH HHS T32 DA007261NINDS NIH HHS R01 NS109170
6 · The paper itself

Abstract

Chronic itch is associated with sensitization of the somatosensory nervous system. Recent studies have identified the neural circuits transmitting acute itch; however, the mechanisms by which itch transforms into a pathological state remain largely unknown. We have previously shown that Aβ low-threshold mechanoreceptors, together with spinal urocortin 3-positive (Ucn3

Indexed as

chronic itchNav1.6NPYspinal cordUcn3

Identifiers

PMID35782385
PMCPMC9244800
OpenAlexW4283018094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.