ReviewOrthopedic reviews2022
Trend of Perioperative CRP (C-Reactive Protein) Levels in Non-Infected Total Knee Arthroplasty.
Review in Orthopedic reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Indicators and medical tests to identify lower limb swelling causes after total knee arthroplasty: a Delphi study with multidisciplinary experts.Journal of orthopaedic surgery and research · 2023Pooled it
- Direct superior approach versus posterolateral approach in mid-term clinical outcomes of total hip arthroplasty: a prospective randomized controlled study.BMC musculoskeletal disorders · 2025Trial
- Synovial fluid proteomic biomarkers in periprosthetic joint infection: A systematic review with gene ontology and protein network analyses.Journal of experimental orthopaedics · 2026Review
- Synovial Fluid Proteomic Biomarkers in Knee Osteoarthritis: A Systematic Review and Gene Ontology Analysis.Cartilage · 2026Review
- Robotic arm-assisted total knee arthroplasty reduces postoperative inflammatory response and blood loss compared to manual total knee arthroplasty: A matched-pairs analysis of 688 patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Evaluation of Post-operative Serum Biomarkers (D-Dimer, ESR, and CRP) in Patients Following Total Joint Arthroplasty: A Prospective Observational Study.Journal of orthopaedic case reports · 2026Article
- Total elbow arthroplasty for distal humeral fractures in the elderly population: good functional outcomes and a high implant survival rate can be expected after surgery.Frontiers in surgery · 2026Article
- Inflammatory-induced swelling after total knee arthroplasty: Obesity and preoperative joint pain as key predictors.Arthroplasty (London, England) · 2025Article
- Nomogram to predict periprosthetic joint infection after total hip arthroplasty using laboratory tests.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Article
- Impact of metoprolol combined with spironolactone on cardiac function in patients with coronary heart disease complicated by heart failure.American journal of translational research · 2025Article
- Risk analyses for perioperative morbidities after aseptic knee revision arthroplasty.Archives of orthopaedic and trauma surgery · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this prospective study was to define the perioperative trend of C-reactive protein (CRP) in non-infected total knee arthroplasty (TKA). CRP was evaluated in 42 patients the day before surgery and 4 and 30 days after surgery. Functional and radiological evaluation was scheduled for 3, 6, and 12 months after surgery. Preoperatively, the median CRP was 3.2 mg/L (IQR,3.2-4.2) (reference range, 0-5 mg/L); 4 and 30 days after surgery, it measured 57.6 mg/L (IQR,36.1-96.4) and 5.3 mg/L (IQR,3.0-11.8), respectively. There were significant differences between the CRP preoperatively and 4 days after surgery (p<0.001) and between CPR levels 4 and 30 days after surgery (p<0.001) but not between CRP values preoperatively and 30 days after surgery (p=0.181). Higher preoperative CRP was associated to heart disease and chronic renal failure (r=0.329, p=0.036, and r=0.437, p=0.004, respectively). Four days after surgery, higher CRP was associated to older patients (r=0.311, p=0.048). In summary, 30 days after primary non-infected TKA, CRP levels were comparable to preoperative values. Older age and comorbidities should be carefully evaluated using postoperative CRP as diagnostic marker for the early detection of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.