Evidence map›Paper›PMID 35782059›Full record

SynthesisBioMed research international2022

A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population.

Hafeez Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ch'ng Ewe Seng, Siti Norasikin Binti Mohd Nafil, Ahmad Aizat Bin Abdul Aziz, Yusuf Wada, Ahmad Irekeola

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Expert consensus on the optimal management of BRAFAsia-Pacific journal of clinical oncology · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hafeez AfolabiDepartment of General Surgery, School of Medical Sciences, Universiti Sains Malaysia Hospital, Malaysia.ORCID https://orcid.org/0000-0002-1120-4100
Salzihan Md SallehDepartment of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia.ORCID https://orcid.org/0000-0001-6691-4962
Zaidi ZakariaDepartment of General Surgery, School of Medical Sciences, Universiti Sains Malaysia Hospital, Malaysia.ORCID https://orcid.org/0000-0003-1644-3546
Ch'ng Ewe SengDepartment of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia.ORCID https://orcid.org/0000-0001-8831-8678
Siti Norasikin Binti Mohd NafilDepartment of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia.ORCID https://orcid.org/0000-0002-0642-0909
Ahmad Aizat Bin Abdul AzizSchool of Medical Sciences, Hospital Universiti Sains Malaysia HUSM, Universiti Sains Malaysia USM, Kubang Kerian, 16150 Kelantan, Malaysia.
Yusuf WadaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia.ORCID https://orcid.org/0000-0003-0003-9581
Ahmad IrekeolaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia.ORCID https://orcid.org/0000-0002-1779-9571
Universiti Sains Malaysia · MYHospital Universiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, colorectal carcinoma (CRC) is the third most common cancer and the third major cause of cancer-related death in both sexes. KRAS and BRAF mutations are almost mutually exclusively involved in the pathogenesis of CRC. Both are major culprits in treatment failure and poor prognosis for CRC.

Indexed as

Colorectal NeoplasmsProto-Oncogene Proteins B-rafBiomarkersCodonFemaleHumansMaleMutationPakistanProto-Oncogene Proteins p21(ras)BiomarkersCodonProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)

Identifiers

PMID35782059
PMCPMC9246611
OpenAlexW4283360922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.