ArticleBiomedical optics express2022
High-speed 3D imaging flow cytometry with optofluidic spatial transformation.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- An Integrated Micromirror System for High-Throughput Multi-Parametric Cell Imaging.Small methods · 2026Article
- LFC-Lab on a chip · 2026Article
- Neuromorphic-enabled video-activated cell sorting.Nature communications · 2024Article
- Review
- Portable light-sheet optofluidic microscopy for 3D fluorescence imaging flow cytometry.Lab on a chip · 2023Article
- High-speed 3D imaging flow cytometry with optofluidic spatial transformation.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional (3D) fluorescence imaging is important to accurately capture and understand biological structures and phenomena. However, because of its slow acquisition speed, it was difficult to implement 3D fluorescence imaging for imaging flow cytometry. Especially, modern flow cytometers operate at a flow velocity of 1-10 m/s, and no 3D fluorescence imaging technique was able to capture cells at such high velocity. Here, we present a high-speed 3D fluorescence imaging technique in which a set of optical cross sections of a cell is captured within a single frame of a camera by combining strobe light-sheet excitation and optofluidic spatial transformation. Using this technique, we demonstrated 3D fluorescence imaging of cells flowing at a velocity of over 10 m/s, which is the fastest to our knowledge. Such technology can allow integration of 3D imaging with flow systems of common flow cytometers and cell sorters.
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Registered trials
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