ArticleBiomedical optics express2022
Label-free plasmonic immunosensor for cortisol detection in a D-shaped optical fiber.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 127 citations in OpenAlex.
- Surface-Modified Extrinsic Semi-Distributed Interferometers for Fiber-Optic Refractive Index Detection and Biosensing.Biosensors · 2026Article
- Spiral-Grating Tapered Gold Tip Used for Micro-Nanoscale Multi-Functional Sensing.Sensors (Basel, Switzerland) · 2026Review
- A rigorous theoretical model of fluorescence-based fiber optic sensors: application to D-shaped fibers.Scientific reports · 2025Article
- Review
- An Efficient Bio-Receptor Layer Combined with a Plasmonic Plastic Optical Fiber Probe for Cortisol Detection in Saliva.Biosensors · 2024Article
- Introduction to the feature issue: Advances in Optical Biosensors for Biomedical Applications.Biomedical optics express · 2024Article
- All-fiber label-free optical fiber biosensors: from modern technologies to current applications [Invited].Biomedical optics express · 2024Review
- Portable optical fiber biosensors integrated with smartphone: technologies, applications, and challenges [Invited].Biomedical optics express · 2024Review
- Photonic Crystal Surface Mode Real-Time Imaging of RAD51 DNA Repair Protein Interaction with the ssDNA Substrate.Biosensors · 2024Article
- WaveFlex biosensor based on S-tapered and waist-expanded technique for detection of glycosylated hemoglobin.Biomedical optics express · 2023Article
- Advances in Tapered Optical Fiber Sensor Structures: From Conventional to Novel and Emerging.Biosensors · 2023Review
- The Importance of Monitoring Cortisol in the Agri-Food Sector-A Systematic Review.Metabolites · 2023Review
- Microfluidic immunosensor based on a graphene oxide functionalized double helix microfiber coupler for anti-Müllerian hormone detection.Biomedical optics express · 2023Article
- Gold Nanoparticle-Based Plasmonic Biosensors.Biosensors · 2023Review
- Cortisol Immunosensors: A Literature Review.Biosensors · 2023Review
- Progress and Trends of Optical Microfiber-Based Biosensors.Biosensors · 2023Review
- Multifunctional Integration of Optical Fibers and Nanomaterials for Aircraft Systems.Materials (Basel, Switzerland) · 2023Review
- Review
- Novel Optical Fiber-Based Structures for Plasmonics Sensors.Biosensors · 2022Review
- Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Measuring cortisol levels as a stress biomarker is essential in many medical conditions associated with a high risk of metabolic syndromes such as anxiety and cardiovascular diseases, among others. One technology that has a growing interest in recent years is fiber optic biosensors that enable ultrasensitive cortisol detection. Such interest is allied with progress being achieved in basic interrogation, accuracy improvements, and novel applications. The development of improved cortisol monitoring, with a simplified manufacturing process, high reproducibility, and low cost, are challenges that these sensing mechanisms still face, and for which solutions are still needed. In this paper, a comprehensive characterization of a D-shaped fiber optic immunosensor for cortisol detection based on surface plasmon resonance (SPR) enabled by gold coating is reported. Specifically, the sensor instrumentation and fabrication processes are discussed in detail, and a simulation with its complete mathematical formalism is also presented. Moreover, experimental cortisol detection tests were performed for a detection range of 0.01 to 100 ng/mL, attaining a logarithmic sensitivity of 0.65 ± 0.02 nm/log(ng/mL) with a limit of detection (LOD) of 1.46 ng/mL. Additionally, an investigation of signal processing is also discussed, with the main issues addressed in order to highlight the best way to extract the sensing information from the spectra measured with a D-shaped sensor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.