Evidence map›Paper›PMID 35781952›Full record

ArticleBiomedical optics express2022

Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways.

Tabea Kohlfaerber, Mario Pieper, Michael Münter, Cornelia Holzhausen, Martin Ahrens, Christian Idel, Karl-Ludwig Bruchhage, Anke Leichtle, Peter König, Gereon Hüttmann and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04614324 (A Prospective, Open Label, Multi-Center Study Using the RhinAer Procedure for Treatment of Subjects Suffering With Chronic Rhinitis), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04614324 nacompletednot on this map

A Prospective, Open Label, Multi-Center Study Using the RhinAer Procedure for Treatment of Subjects Suffering With Chronic Rhinitis

TypeinterventionalSponsorAerin MedicalRan2020 to 2024Enrolled129ConditionsChronic RhinitisArmsRhinAer ARC Stylus
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Label-free viability assessment ofBiomedical optics express · 2026
    Article
  5. Review
  6. Guide to dynamic OCT data analysis.Biomedical optics express · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Optical Imaging of Cilia in the Head and Neck.Journal of clinical medicine · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tabea KohlfaerberMedizinisches Laserzentrum Lübeck GmbH, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0003-3789-539X
Mario PieperUniversity of Lübeck, Institute of Anatomy, Ratzeburger Allee 160, 23562 Lübeck, Germany.
Michael MünterUniversity of Lübeck, Institute of Biomedical Optics, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0002-8004-3646
Cornelia HolzhausenUniversity of Lübeck, Institute of Anatomy, Ratzeburger Allee 160, 23562 Lübeck, Germany.
Martin AhrensAirway Research Center North Member of the German Center for Lung Research, DZL, 22927 Großhansdorf, Germany.
Christian IdelUniversity Hospital Schleswig-Holstein, ENT Clinics, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Karl-Ludwig BruchhageUniversity Hospital Schleswig-Holstein, ENT Clinics, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Anke LeichtleUniversity Hospital Schleswig-Holstein, ENT Clinics, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Peter KönigUniversity of Lübeck, Institute of Anatomy, Ratzeburger Allee 160, 23562 Lübeck, Germany.
Gereon HüttmannMedizinisches Laserzentrum Lübeck GmbH, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0002-5051-3037
Hinnerk Schulz-HildebrandtMedizinisches Laserzentrum Lübeck GmbH, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0003-4389-9151
German Center for Lung Research · DEMedizinisches Laserzentrum Lübeck (Germany) · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the imaging of airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using fast sequences of microscopic resolution OCT (mOCT) images, OCT can use small signal fluctuations to overcome lack in contrast and speckle noise. In this way, OCT visualizes airway morphology on a cellular level and allows the tracking of the dynamic behavior of immune cells, as well as mucus transport and secretion. Here, we demonstrate that mOCT, by using temporal tissue fluctuation as contrast (dynamic mOCT), provides the possibility to study physiological and pathological tissue processes

Identifiers

PMID35781952
PMCPMC9208592
OpenAlexW4224218891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.