ArticleActa crystallographica. Section A, Foundations and advances2022
Random conical tilt reconstruction without particle picking in cryo-electron microscopy.
Article in Acta crystallographica. Section A, Foundations and advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Structure determination using high-order spatial correlations in single-particle X-ray scattering.IUCrJ · 2024Article
- MULTI-TARGET DETECTION WITH ROTATIONS.Inverse problems and imaging (Springfield, Mo.) · 2023Article
- Toward Single Particle Reconstruction without Particle Picking: Breaking the Detection Limit.SIAM journal on imaging sciences · 2023Article
- Transformations between rotational and translational invariants formulated in reciprocal spaces.Journal of structural biology: X · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
A method is proposed to reconstruct the 3D molecular structure from micrographs collected at just one sample tilt angle in the random conical tilt scheme in cryo-electron microscopy. The method uses autocorrelation analysis on the micrographs to estimate features of the molecule which are invariant under certain nuisance parameters such as the positions of molecular projections in the micrographs. This enables the molecular structure to be reconstructed directly from micrographs, completely circumventing the need for particle picking. Reconstructions are demonstrated with simulated data and the effect of the missing-cone region is investigated. These results show promise to reduce the size limit for single-particle reconstruction in cryo-electron microscopy.
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