Evidence map›Paper›PMID 35781219›Full record

ArticleAdvances in experimental medicine and biology2022

Virus, Exosome, and MicroRNA: New Insights into Autophagy.

Javid Sadri Nahand, Arash Salmaninejad, Samaneh Mollazadeh, Seyed Saeed Tamehri Zadeh, Mehdi Rezaee, Amir Hossein Sheida, Fatemeh Sadoughi, Parisa Maleki Dana, Mahdi Rafiyan, Masoud Zamani and 8 more

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  10. Exosomes and microRNAs as mediators of the exercise.European journal of medical research · 2025
    Review
  11. Review
  12. Review
  13. Regulatory role of microRNAs in virus-mediated inflammation.Journal of inflammation (London, England) · 2024
    Review
  14. Article
  15. Review
  16. Exosomes for angiogenesis induction in ischemic disorders.Journal of cellular and molecular medicine · 2023
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Javid Sadri NahandInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Arash SalmaninejadDepartment of Medical Genetics, Faculty of Medicine, Guilan University of Medical Sciences, Guilan, Iran.
Samaneh MollazadehNatural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Seyed Saeed Tamehri ZadehSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi RezaeeDepartment of Anesthesiology, School of Medicine, Shahid Madani Hospital, Alborz University of Medical Sciences, Karaj, Iran.
Amir Hossein SheidaSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Fatemeh SadoughiSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Parisa Maleki DanaSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Mahdi RafiyanSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Masoud ZamaniSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Seyed Pouya TaghaviSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Fatemeh DashtiSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Seyed Mohammad Ali MirazimiSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Hossein Bannazadeh BaghiInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohsen MoghoofeiDepartment of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mohammad KarimzadehDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Massoud VosoughDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Hamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. mirzaei-h@kaums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is known as a conserved self-eating mechanism that contributes to cells to degrade different intracellular components (i.e., macromolecular complexes, aggregated proteins, soluble proteins, organelles, and foreign bodies). Autophagy needs formation of a double-membrane structure, which is composed of the sequestered cytoplasmic contents, called autophagosome. There are a variety of internal and external factors involved in initiation and progression of autophagy process. Viruses as external factors are one of the particles that could be associated with different stages of this process. Viruses exert their functions via activation and/or inhibition of a wide range of cellular and molecular targets, which are involved in autophagy process. Besides viruses, a variety of cellular and molecular pathways that are activated and inhibited by several factors (e.g., genetics, epigenetics, and environment factors) are related to beginning and developing of autophagy mechanism. Exosomes and microRNAs have been emerged as novel and effective players anticipated in various stages of autophagy. More knowledge in these pathways and identification of accurate roles of them could help to provide better therapeutic approaches in several diseases such as cancer. We highlighted the roles of viruses, exosomes, and microRNAs in the autophagy processes.

Indexed as

ExosomesMicroRNAsVirusesAutophagosomesAutophagyMicroRNAsAutophagyCancerChemoresistanceExosomeMicroRNAViral infection

Identifiers

PMID35781219

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.