ArticleNeuroImage. Clinical2022
Neural correlates of working memory and compensation at different stages of cognitive impairment in Parkinson's disease.
Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Abnormalities of cerebral blood flow and the regional brain function in Parkinson's disease: a systematic review and multimodal neuroimaging meta-analysis.Frontiers in neurology · 2023Pooled it
- Parkinson's disease progression is shaped by longitudinal changes in cerebral compensation.Brain : a journal of neurology · 2026Article
- Explainable machine learning algorithm predicting working memory performance in Parkinson's disease using task-fMRI.Journal of neurology · 2025Article
- Neurophysiological underpinnings of balance control and cognitive-motor interaction in early Parkinson's disease.Scientific reports · 2025Article
- Speech Acoustic Markers Can Detect Mild Cognitive Impairment in Parkinson's Disease.IEEE journal of selected topics in signal processing · 2025Article
- Observational
- Stage-specific functional networks associated with cognitive impairment in Parkinson's disease: a pilot fNIRS study.Frontiers in aging neuroscience · 2025Article
- Harmonization for Parkinson's Disease Multi-Dataset T1 MRI Morphometry Classification.NeuroSci · 2024Article
- Naturalistic assessment of everyday multitasking in Parkinson's disease with and without mild cognitive impairment.The Clinical neuropsychologist · 2024Article
- Magnetic resonance imaging of brain structural and functional changes in cognitive impairment associated with Parkinson's disease.Frontiers in aging neuroscience · 2024Review
- Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes.Annals of clinical and translational neurology · 2023Article
- Working memory characteristics in T2DM individuals with MMSE-defined cognitive status: a behavioral study.Frontiers in neurologyArticle
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Working memory (WM) impairment is one of the most frequent cognitive deficits in Parkinson's disease (PD). However, it is not known how neural activity is altered and compensatory responses eventually fail during progression. We aimed to elucidate neural correlates of WM and compensatory mechanisms in PD. Eighteen cognitively normal PD patients (PD-CogNL), 16 with PD with mild cognitive impairment (PD-MCI), 11 with PD with dementia (PDD), and 17 healthy controls (HCs) were evaluated. Subjects performed an n-back task. Functional MRI data were analyzed by event-related analysis for correct responses. Brain activations were evaluated by comparing them to fixation cross or 0-back task, and correlated with n-back task performance. When compared to fixation cross, PD-CogNL patients had more activation in WM areas than HCs for both the 2- and 3-back tasks. PD-MCI and PDD patients had more activation in WM areas than HCs for the 0- and 1-back task. 2-back task performance was correlated with brain activations (vs. 0-back task) in the bilateral dorsolateral prefrontal cortex and frontal eye field (FEF) and left rostral prefrontal cortex, caudate nucleus, inferior/superior parietal lobule (IPL/SPL), and anterior insular cortex as well as anterior cingulate cortex. 3-back task performance was correlated with brain activations (vs. 0-back task) in the left FEF, right caudate nucleus, and bilateral IPL/SPL. Additional activations on top of the 0-back task, rather than fixation cross, are the neural correlates of WM. Our results suggest PD patients have two types of compensatory mechanisms: (1) Hyperactivation for different WM load tasks depending on their cognitive status. PD-CogNL have hyperactivation for moderate and heavy working memory load tasks while maintaining normal working memory performance. In contrast, PD-MCI and PDD have hyperactivation for control task and light working memory load task, leaving less neural resources to further activate for more demanding tasks and resulting in impaired working memory performance. (2) Bilateral recruitment of WM-related areas, in particular the DLPFC, FEF, IPL/SPL and caudate nucleus, to improve WM performance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.