Evidence map›Paper›PMID 35780565›Full record

ArticleThe International journal on drug policy2022

Navigating Opioid Agonist Therapy among Young People who use Illicit Opioids in Vancouver, Canada.

Andreas Pilarinos, Yandi Kwa, Ronald Joe, Madison Thulien, Jane A Buxton, Kora DeBeck, Danya Fast

Open access · hybridAbstract read
In one paragraph

Article in The International journal on drug policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Methadone Maintenance Treatment Discontinuation Among Young People who use Opioids in Vancouver, Canada.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Andreas PilarinosBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, Canada, V6Z 2A9; Interdisciplinary Studies Graduate Program, University of British Columbia, 270-2357 Main Mall, Vancouver, BC, Canada V6T 1Z4.
Yandi KwaVancouver Coastal Health, 520 West 6(th) Avenue, Vancouver, BC, Canada, V5Z 1A1.
Ronald JoeVancouver Coastal Health, 520 West 6(th) Avenue, Vancouver, BC, Canada, V5Z 1A1.
Madison ThulienBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, Canada, V6Z 2A9.
Jane A BuxtonSchool of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, Canada, V6T 1Z3.
Kora DeBeckBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, Canada, V6Z 2A9; School of Public Policy, Simon Fraser University, 515 West Hastings Street, Suite 3271, Vancouver, BC, Canada, V6B 5K3.
Danya FastBritish Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, Canada, V6Z 2A9; Department of Medicine, University of British Columbia, 317-2914 Health Sciences Mall, Vancouver, BC, Canada, V6T1Z3. Electronic address: danya.fast@ubc.ca.
University of British Columbia · CAVancouver Coastal Health · CABritish Columbia Centre on Substance Use · CASimon Fraser University · CA

Funding

Vancouver Drug Users Study: The Impacts of Evolving Drug Use Patterns on HIV/AIDSU01DA038886 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI DEBECK, KORA, HAYASHI, KANNA · 2015 to 2024
$12.1M
Impacts of universal access to HIV/AIDS care among HIV+ injection drug usersU01DA021525 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI MILLOY, M-J · 2017 to 2024
$4.3M
An ethno-epidemiological study of the implementation and effectiveness of an innovative and comprehensive response to the opioid epidemicR01DA044181 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI Thomas Kerr, Ryan McNeil · 2017 to 2026
$4.0M
NIDA NIH HHS R01 DA044181NIDA NIH HHS U01 DA021525NIDA NIH HHS U01 DA038886
6 · The paper itself

Abstract

backgroundOpioid agonist therapy (OAT) has been shown to reduce opioid use and related harms. However, many young people are not accessing OAT. This study sought to explore how young people navigated OAT over time, including periods of engagement, disengagement, and avoidance.

methodsSemi-structured, in-depth qualitative interviews were conducted between January 2018 and August 2020 with 56 young people in Vancouver, Canada who reported illicit, intensive heroin and/or fentanyl use. Following the verbatim transcription of longitudinal interviews, an iterative thematic analysis was used to extrapolate key themes.

resultsYoung people contemplating OAT expressed fears about its addictiveness. Many experienced pressure from providers and family members to initiate buprenorphine-naloxone, despite a desire to explore other treatment options such as methadone. Once young people initiated OAT, staying on it was difficult and complicated by daily witnessed dosing requirements and strict rules around repeated missed doses, especially for those receiving methadone. Most young people envisioned tapering off OAT in the not-too-distant future.

conclusionsFindings underscore the importance of working collaboratively with young people to develop treatment plans and timelines, and suggest that OAT engagement and retention among young people could be improved by expanding access to the full range of OAT; updating clinical guidelines to improve access to safer prescription alternatives to the increasingly poisonous, unregulated drug supply; addressing treatment gaps arising from missed doses and take-home dosing; and providing a clear pathway to OAT tapering.

Indexed as

Analgesics, OpioidOpioid-Related DisordersAdolescentBuprenorphine, Naloxone Drug CombinationCanadaHumansMethadoneOpiate Substitution TreatmentAnalgesics, OpioidBuprenorphine, Naloxone Drug CombinationMethadoneCOVID-19 pandemicOpioid agonist therapyopioid use disorderoverdoseyoung people

Identifiers

PMID35780565
PMCPMC9872974
OpenAlexW4283744536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.