Evidence map›Paper›PMID 35780511›Full record

Trial reportEuropean eating disorders review : the journal of the Eating Disorders Association2022

Autistic characteristics in youth with anorexia nervosa before and after treatment.

Annabel Susanin, Marita Cooper, Amanda Makara, Emily S Kuschner, C Alix Timko

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European eating disorders review : the journal of the Eating Disorders Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03928028 (Shifting Perspectives), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03928028 nacompletednot on this map

Shifting Perspectives: Enhancing Outcomes in Adolescent Anorexia Nervosa With Cognitive Remediation Therapy (CRT)

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2019 to 2021Enrolled177ConditionsAnorexia NervosaArmsCognitive Remediation Therapy, Family Based Treatment
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Annabel SusaninDepartment of Psychiatry, Eating and Weight Disorder Program, Icahn School of Medicine, New York, New York, USA.
Marita CooperDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Amanda MakaraDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Emily S KuschnerDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
C Alix TimkoDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Shifting Perspectives: Enhancing outcomes in adolescent anorexia nervosa with cognitive remediation therapyR33MH119262 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI TIMKO, C. ALIX · 2021 to 2023
$2.4M
Shifting Perspectives: Enhancing outcomes in adolescent anorexia nervosa with cognitive remediation therapyR61MH119262 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI TIMKO, C. ALIX · 2019 to 2020
$1.4M
NIMH NIH HHS R33 MH119262NIMH NIH HHS R61 MH119262
6 · The paper itself

Abstract

objectiveCognitive characteristics common to autistic individuals are often seen in adults with anorexia nervosa (AN), raising the question of whether autistic people and people with AN may share an endophenotype. We need to examine autistic characteristics during the early stages of AN to accurately parse true symptom co-occurrence from behavioural alterations due to prolonged illness.

methodsWe conducted a post-hoc analysis examining autistic characteristics in 59 youth with AN. Adolescents and parents participating in a randomised-clinical trial for AN completed questionnaires probing autistic characteristics at baseline and treatment end. We categorised participants as above or below cut-offs of clinical indicators of autism using the Autism Probability Index (API) and the Autism Spectrum Quotient-10.

resultsRates of high autistic characteristics ranged between 0% and 36% depending on the instrument used and how the data was obtained (i.e., by informant report or self-report). Paternal report of autistic characteristics differed across treatment completers versus non completers and maternal report indicated lower weight gain for those with elevated characteristics.

conclusionsLow rates of autism and fluctuations in autistic features during treatment underscore the importance of longitudinal examinations of autistic characteristics in adolescents with AN. Future studies need to replicate findings in a larger adolescent sample.

trial registrationClinicalTrails.gov Identifier NCT03928028.

Indexed as

Anorexia NervosaAutism Spectrum DisorderAutistic DisorderAdolescentAdultHumansSelf ReportSurveys and Questionnairesadolescentsanorexia nervosaautism

Identifiers

PMID35780511
PMCPMC10243230
OpenAlexW4283784394

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.