ArticleMacromolecular bioscience2022
Exploiting Meltable Protein Hydrogels to Encapsulate and Culture Cells in 3D.
Article in Macromolecular bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Sodium Alginate Hydrogel Sponges Embedded with M2 Macrophages: An Adoptive Cell Therapy Strategy for Accelerated Diabetic Wound Healing.Gels (Basel, Switzerland) · 2025Article
- Quantification of local matrix deposition during muscle stem cell activation using engineered hydrogels.bioRxiv : the preprint server for biology · 2024Article
- The polymer and materials science of the bacterial fimbriae Caf1.Biomaterials science · 2023Review
- Exploiting Meltable Protein Hydrogels to Encapsulate and Culture Cells in 3D.Macromolecular bioscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a growing realization that 3D cell culture better mimics complex in vivo environments than 2D, lessening aberrant cellular behaviors and ultimately improving the outcomes of experiments. Chemically crosslinked hydrogels which imitate natural extracellular matrix (ECM) are proven cell culture platforms, but the encapsulation of cells within these hydrogel networks requires bioorthogonal crosslinking chemistries which can be cytotoxic, synthetically demanding, and costly. Capsular antigen fragment 1 (Caf1) is a bacterial, polymeric, fimbrial protein which can be genetically engineered to imitate ECM. Furthermore, it can, reversibly, thermally interconvert between its polymeric and monomeric forms even when chemically crosslinked within a hydrogel network. It is demonstrated that this meltable feature of Caf1 hydrogels can be utilized to encapsulate neonatal human dermal fibroblasts at a range of cell densities (2 × 10
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Registered trials
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