Evidence map›Paper›PMID 35780449›Full record

ArticleSleep2023

Scoring sleep with artificial intelligence enables quantification of sleep stage ambiguity: hypnodensity based on multiple expert scorers and auto-scoring.

Jessie P Bakker, Marco Ross, Andreas Cerny, Ray Vasko, Edmund Shaw, Samuel Kuna, Ulysses J Magalang, Naresh M Punjabi, Peter Anderer

Abstract read
In one paragraph

Article in Sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  7. Temporally Continuous Automated Sleep-Wake Classification Using Deep Learning.medRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jessie P BakkerPhilips Sleep and Respiratory Care, Pittsburgh, PA,USA.ORCID 0000-0002-2976-4747
Marco RossPhilips Sleep and Respiratory Care, Vienna, Austria.ORCID 0000-0003-0603-5709
Andreas CernyPhilips Sleep and Respiratory Care, Vienna, Austria.ORCID 0000-0001-8191-1866
Ray VaskoPhilips Sleep and Respiratory Care, Pittsburgh, PA,USA.
Edmund ShawPhilips Sleep and Respiratory Care, Pittsburgh, PA,USA.
Samuel KunaPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA,USA.
Ulysses J MagalangDivision of Pulmonary, Critical Care, and Sleep Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0002-5052-2494
Naresh M PunjabiDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miami FL, USA.
Peter AndererPhilips Sleep and Respiratory Care, Vienna, Austria.ORCID 0000-0002-3869-6678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesTo quantify the amount of sleep stage ambiguity across expert scorers and to validate a new auto-scoring platform against sleep staging performed by multiple scorers.

methodsWe applied a new auto-scoring system to three datasets containing 95 PSGs scored by 6-12 scorers, to compare sleep stage probabilities (hypnodensity; i.e. the probability of each sleep stage being assigned to a given epoch) as the primary output, as well as a single sleep stage per epoch assigned by hierarchical majority rule.

resultsThe percentage of epochs with 100% agreement across scorers was 46 ± 9%, 38 ± 10% and 32 ± 9% for the datasets with 6, 9, and 12 scorers, respectively. The mean intra-class correlation coefficient between sleep stage probabilities from auto- and manual-scoring was 0.91, representing excellent reliability. Within each dataset, agreement between auto-scoring and consensus manual-scoring was significantly higher than agreement between manual-scoring and consensus manual-scoring (0.78 vs. 0.69; 0.74 vs. 0.67; and 0.75 vs. 0.67; all p < 0.01).

conclusionsAnalysis of scoring performed by multiple scorers reveals that sleep stage ambiguity is the rule rather than the exception. Probabilities of the sleep stages determined by artificial intelligence auto-scoring provide an excellent estimate of this ambiguity. Compared to consensus manual-scoring, sleep staging derived from auto-scoring is for each individual PSG noninferior to manual-scoring meaning that auto-scoring output is ready for interpretation without the need for manual adjustment.

Indexed as

Artificial IntelligenceSleepHumansObserver VariationReproducibility of ResultsSleep Stagesartificial intelligencehypnodensitymachine learningpolysomnographysleep stagesvalidation

Identifiers

PMID35780449
PMCPMC9905781

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.