Evidence map›Paper›PMID 35780424›Full record

ArticleEuropean journal of nutrition2022

Prospective dietary polyunsaturated fatty acid intake is associated with trajectories of fatty liver disease: an 8 year follow-up study from adolescence to young adulthood.

Fuzhen Wan, Feng Pan, Oyekoya Ayonrinde, Leon A Adams, Trevor A Mori, Lawrence J Beilin, Therese A O'Sullivan, John K Olynyk, Wendy H Oddy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Fuzhen WanNutritional Epidemiology, Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
Feng PanNutritional Epidemiology, Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
Oyekoya AyonrindeMedical School, The University of Western Australia, Perth, WA, Australia.
Leon A AdamsMedical School, The University of Western Australia, Perth, WA, Australia.
Trevor A MoriMedical School, The University of Western Australia, Perth, WA, Australia.
Lawrence J BeilinMedical School, The University of Western Australia, Perth, WA, Australia.
Therese A O'SullivanSchool of Medical and Health Science, Edith Cowan University, Perth, WA, Australia.
John K OlynykDepartment of Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch University, Perth, WA, Australia.
Wendy H OddyNutritional Epidemiology, Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia. Wendy.Oddy@utas.edu.au.ORCID http://orcid.org/0000-0002-6119-7017
The University of Western Australia · AUUniversity of Tasmania · AUEdith Cowan University · AUMurdoch University · AU

Funding

National Health and Medical Research Council 003209National Health and Medical Research Council 1021105National Health and Medical Research Council 1021855National Health and Medical Research Council 1022134National Health and Medical Research Council 1027449National Health and Medical Research Council 1044840National Health and Medical Research Council 211912National Health and Medical Research Council 353514National Health and Medical Research Council 403981
6 · The paper itself

Abstract

BACKGROUND AND

aimDietary fat intake has long been associated with fatty liver. Our study aimed to determine the effect of dietary fats on longitudinal fatty liver index (FLI) trajectories from adolescence to young adulthood.

methodsNine hundred eighty-five participants in the Raine Study, Perth, Western Australia, Australia, had cross-sectional assessments at ages 14, 17, 20 and 22 years, during which anthropometric measurements and blood tests were obtained. FLI trajectories were derived from the longitudinal FLI results. Dietary fat intake was measured with a semi-quantitative food frequency questionnaire at 14 years and log multinominal regression analyses were used to estimate relative risks.

resultsThree FLI trajectories were identified and labelled as stable-low (79.1%, N = 782), low-to-high (13.9%, N = 132), and stable-high (7%, N = 71). The low-to-high group associated with an increased intake of the long-chain polyunsaturated fatty acids EPA, DPA and DHA (RR 1.27, 95% CI 1.10-1.48) relative to the stable-low group. Compared to the stable-low group, omega-6 and the ratio of omega-6 to omega-3 in the stable-high group were associated with an increased relative risk of 1.34 (95% CI 1.02-1.76) and 1.10 (95% CI 1.03-1.16), respectively.

conclusionFor those at high risk of fatty liver in early adolescence, high omega-6 fatty acid intake and a high ratio of omega-6 to omega-3 fatty acids are associated with increased risk of fatty liver. There should be caution in assuming these associations are causal due to possible undetected and underestimated confounding factors.

Indexed as

Fatty Acids, Omega-3Fatty LiverLiver DiseasesAdolescentAdultCross-Sectional StudiesDietary FatsFatty AcidsFatty Acids, Omega-6Follow-Up StudiesHumansYoung AdultDietary FatsFatty AcidsFatty Acids, Omega-3Fatty Acids, Omega-6Dietary fatsFatty liverFatty liver indexGroup-based trajectory modelling

Identifiers

PMID35780424
PMCPMC9596520
OpenAlexW4283787730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.