Evidence map›Paper›PMID 35780236›Full record

ArticleJournal of molecular modeling2022

Interaction mechanism of novel fluorescent antifolates targeted with folate receptors α and β via molecular docking and molecular dynamic simulations.

Cuihong Wang, Meiling Zhang, Shuhui Shi, Yue Jiang, Xuening Fei, Lijuan Liu, Dan Ye, Shouchao Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular modeling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cuihong WangSchool of Science, TianJin ChengJian University, Tianjin, China. cuihong1231@163.com.ORCID http://orcid.org/0000-0003-2243-796X
Meiling ZhangSchool of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
Shuhui ShiSchool of Mathematics and Physics, Handan College, Handan, China.
Yue JiangSchool of Science, TianJin ChengJian University, Tianjin, China.
Xuening FeiSchool of Science, TianJin ChengJian University, Tianjin, China. xueningfei@126.com.
Lijuan LiuSchool of Science, TianJin ChengJian University, Tianjin, China.
Dan YeSchool of Science, TianJin ChengJian University, Tianjin, China.
Shouchao ZhangSchool of Science, TianJin ChengJian University, Tianjin, China.
Tianjin Chengjian University · CNHandan College · CNTianjin Medical University · CN

Funding

Aeronautical Science Fund 201834Y2001National Natural Science Foundation of China 10904111National Natural Science Foundation of China 11604238National Natural Science Foundation of China 51778398Scientific Research Plan Project of Tianjin Municipal Education Commission 2018KJ180
6 · The paper itself

Abstract

Eight novel fluorescent antifolates were designed and docked with folate receptors FRα and FRβ. The structures of the complexes were further calculated by molecular dynamic (MD) simulations. The binding energies were calculated by molecular docking and molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) studies. The binding energy differences between FRα and FRβ (|E

Indexed as

Folic Acid AntagonistsMolecular Dynamics SimulationFolic AcidMolecular Docking SimulationFolic AcidFolic Acid AntagonistsFolate receptor subtypeMolecular dockingMolecular dynamicsNovel antifolateTarget recognition

Identifiers

PMID35780236
OpenAlexW4283775951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.