ArticleNature communications2022
Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Humidity as a potential zeitgeber for circadian entrainment of insect systems.Npj biological timing and sleep · 2026Article
- TMEM63B regulates nucleocytoplasmic transport and placental development.Nature communications · 2026Article
- Functional Divergence and Emerging Roles of the ANO-TMC-TMEM63 Channel Families in Olfaction and Gustation.International journal of molecular sciences · 2026Review
- Advances and Prospects in Odour-based Management of Filth Flies.Journal of chemical ecology · 2026Review
- Targeting Tmem63b and Piezo2 in C-fiber low-threshold mechanoreceptors: Limitation of Vglut3-IRES-Cre.Biophysical journal · 2025Article
- Simultaneous recording of spikes and calcium signals in odor-evoked responses ofJournal of neurogenetics · 2025Article
- TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Groove architecture controls lipid scrambling in simulations of protein and model systems.bioRxiv : the preprint server for biology · 2025Article
- Article
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cation Channel TMEM63A Autonomously Facilitates Oligodendrocyte Differentiation at an Early Stage.Neuroscience bulletin · 2025Article
- Non-Immune Functions of Innate Immunity Acting on Physiological Processes: Insights fromInternational journal of molecular sciences · 2025Review
- Article
- Three-dimensional ultrastructural characterization of Drosophila melanogaster hygrosensilla across humidity conditions.PloS one · 2025Article
- A dynamic humidity arena to explore humidity-related behaviours in insects.The Journal of experimental biology · 2024Article
- Mechanisms of mechanotransduction and physiological roles of PIEZO channels.Nature reviews. Molecular cell biology · 2024Review
- IRoning out mosquitoes' attraction to mugginess.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Functional dissection of mosquito humidity sensing reveals distinct Dry and Moist Cell contributions to blood feeding and oviposition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Thirst-driven hygrosensory suppression promotes water seeking inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Expression and localization of the mechanosensitive/osmosensitive ion channel TMEM63B in the mouse urinary tract.Physiological reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Birds, reptiles and insects have the ability to discriminate humidity levels that influence their survival and geographic distribution. Insects are particularly susceptible to humidity changes due to high surface area to volume ratios, but it remains unclear how humidity sensors transduce humidity signals. Here we identified Or42b-expressing olfactory sensory neurons, which are required for moisture attraction in Drosophila. The sensilla housing Or42b neurons show cuticular deformations upon moist air stimuli, indicating a conversion of humidity into mechanical force. Accordingly, we found Or42b neurons directly respond to humidity changes and rely on the mechanosensitive ion channel TMEM63 to mediate humidity sensing (hygrosensation). Expressing human TMEM63B in Tmem63 mutant flies rescued their defective phenotype in moisture attraction, demonstrating functional conservation. Thus, our results reveal a role of Tmem63 in hygrosensation and support the strategy to detect humidity by transforming it into a mechanical stimulus, which is unique in sensory transduction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.