ArticleDiagnostic pathology2022
A retrospective analysis of serous effusions based on the newly proposed international system for reporting serous fluid cytopathology: a report of 3633 cases in an oncological center.
Article in Diagnostic pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 21 citations in OpenAlex.
- [Clinical Application of the International System for Serous Fluid Cytopathology in the Stratified Diagnosis of Lung Cancer-associated Serous Effusions].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Article
- Ensemble based in transfer learning for cytological classification in pleural fluid.Frontiers in digital health · 2026Article
- Three Years of Idiopathic Chylous Ascites: Splenic Marginal Zone Lymphoma Behind the Mask.Cureus · 2026Article
- Cytopathological evaluation of serous effusions using the ISRSFC system: Risk of malignancy and demographic associations in a Saudi cohort.Saudi medical journal · 2025Observational
- Vaginal Tumor Cell Exfoliation in Cervical and Endometrial Cancer: A Comparative Washing Cytology Study with Implications for Minimally Invasive Surgery.Journal of clinical medicine · 2025Article
- Deciphering Serous Effusions Using the New International System for Reporting Serous Fluid Cytopathology.Cureus · 2024Article
- The International System for Reporting Serous Fluid Cytopathology-An Updated Review.Journal of clinical and translational pathology · 2023Article
- Role of Ancillary Techniques in Reporting Serous Fluid Cytology - "Redefining Categories, Refining Diagnosis".Journal of cytologyArticle
- The International System for Reporting Serous Fluid Cytopathology: The Need for Version 2.0.Journal of cytologyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundThe International System for Reporting Serous Fluid Cytopathology (TIS) was recently proposed. We retrospectively applied TIS recommendations for reporting the cytological diagnosis of serous effusions and reported our experience.
methodsAll the serous effusions from January 2018 to September 2021 were retrieved from the database. Recategorization was performed using the TIS classification, the risk of malignancy (ROM) was calculated for each TIS category. In addition, on the basis of the original TIS classification, we further subdivided the TIS category IV (suspicious for malignancy, SFM) into 2 groups (IVa and IVb) according to cytological characteristics (quality and quantity) to explore the necessity of SFM subclassification. The performance evaluation was carried out using different samples (pleural, peritoneal and pericardial effusions) and preparation methods (conventional smears, liquid-based preparations and cell blocks).
resultsA total of 3633 cases were studied: 17 (0.5%) were diagnosed as 'nondiagnostic' (I, ND), 1100 (30.3%) as 'negative for malignancy' (II, NFM), 101 (2.8%) as 'atypia of undetermined significance' (III, AUS), 677 (18.6%) as 'suspicious for malignancy' (IV, SFM), and 1738 (47.8%) as 'malignant' (V, MAL). The ROMs for the categories were 38.5%, 28.6%, 52.1%, 99.4% and 100%, respectively. The ROM for SFM was significantly higher than that for AUS (P < 0.001), while the difference between the ROMs for IVa and IVb was insignificant. The sensitivity, negative predictive value (NPV) and diagnostic accuracy of liquid-based preparations were all superior to those of conventional smears and cell blocks in detecting abnormalities. Using the three preparation methods simultaneously had the highest sensitivity, NPV and diagnostic accuracy.
conclusionSerous effusion cytology has a high specificity and positive predictive value (PPV), and TIS is a user-friendly reporting system. Liquid-based preparations could improve the sensitivity of diagnosis, and it is best to use three different preparation methods simultaneously for serous effusion cytologic examination.
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