ArticleAging2022
A bi-directional Mendelian randomization study of the sarcopenia-related traits and osteoporosis.
Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis.PloS one · 2024Pooled it
- MRI-based pedicle bone quality score predicts cage subsidence following oblique lumbar interbody fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Bridging bone and muscle: ontology-driven prioritization of candidate genes at the osteoporosis-sarcopenia interface by gene ontology reverse lookup.Frontiers in genetics · 2026Article
- Exploration of Crucial miRNA Signatures and Molecular Mechanisms in the System of Muscle-Exosome-Bone: Evidence from Transcriptome Data.ACS omega · 2025Article
- Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study.BMC medicine · 2025Article
- CHST3, PGBD5, and SLIT2 can be identified as potential genes for the diagnosis and treatment of osteoporosis and sarcopenia.Scientific reports · 2025Article
- Osteosarcopenia: key molecular mechanisms and translational perspectives.Frontiers in physiology · 2025Review
- Causal relationship between lipid profile and muscle atrophy: A bi-directional Mendelian randomization study.Animal models and experimental medicine · 2025Article
- Serum uric acid/creatinine ratio and osteoporosis in the elderly: a NHANES study.Frontiers in medicine · 2025Article
- Associations of Body Mass Index and Percent Body Fat with Osteoporosis, Sarcopenia, and Osteosarcopenia: A Retrospective Study Based on Postmenopausal Women in China.Healthcare (Basel, Switzerland) · 2024Article
- Mendelian randomization study on association between grip strength and BMD in different age groups.Journal of bone and mineral metabolism · 2024Article
- Association Between Advanced Glycation End Products and Sarcopenia: The Mediating Role of Osteoporosis.The Journal of clinical endocrinology and metabolism · 2024Article
- The genetic causal effect of hand grip strength on osteoporosis and falling risk: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Nucleotide polymorphism-based study utilizes human plasma liposomes to discover potential therapeutic targets for intervertebral disc disease.Frontiers in endocrinology · 2024Article
- Causal associations between autoimmune diseases and sarcopenia-related traits: a bi-directional Mendelian randomization study.Frontiers in genetics · 2024Article
- Association between sarcopenia and osteoporosis: the cross-sectional study from NHANES 1999-2020 and a bi-directions Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases.Frontiers in genetics · 2024Article
- Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue.Scientific reports · 2023Article
- The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Both sarcopenia and osteoporosis are common geriatric diseases causing huge socioeconomic burdens, and clinically, they often occur simultaneously. Observational studies have found a controversial correlation between sarcopenia and osteoporosis and their causal relationship is not clear. Therefore, we performed a bi-directional two-sample Mendelian randomization (MR) analysis to assess the potential causal relationship between sarcopenia-related traits (hand grip strength, lean mass, walking pace) and osteoporosis. Our analysis was performed by applying genetic variants obtained from the UK Biobank and the GEnetic Factors for OSteoporosis (GEFOS) datasets. We used inverse-variance weighted (IVW) and several sensitivity analyses to estimate and cross-validate the potential causal relationship in this study. We found that bone mineral density (BMD) was causally positively associated with left-hand grip strength (β = 0.017,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.