Evidence map›Paper›PMID 35779476›Full record

ArticleCell calcium2022

Altered composition of the mitochondrial Ca

Melanie Paillard, Kai-Ting Huang, David Weaver, Jonathan P Lambert, John W Elrod, György Hajnóczky

Open access · greenAbstract read
In one paragraph

Article in Cell calcium, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026
    Article
  3. Increased Intermembrane Space [CaCirculation research · 2025
    Article
  4. Review
  5. Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. MICU1's calcium sensing beyond mitochondrial calcium uptake.Biochimica et biophysica acta. Molecular cell research · 2024
    Review
  16. Review
  17. Mitochondrial CaJACC. Basic to translational science · 2024
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Melanie PaillardMitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States of America; Current address: Laboratoire CarMeN - IRIS Team, INSERM, INRA, Université Claude Bernard Lyon-1, INSA-Lyon, Univ-Lyon, 69500 Bron, France.
Kai-Ting HuangMitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.
David WeaverMitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.
Jonathan P LambertCardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania 19140, United States of America.
John W ElrodCardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania 19140, United States of America. Electronic address: elrod@temple.edu.
György HajnóczkyMitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States of America. Electronic address: gyorgy.hajnoczky@jefferson.edu.
Thomas Jefferson University · USTemple University · USUniversité Claude Bernard Lyon 1 · FR

Funding

Targeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KOCH, WALTER J. · 2020 to 2024
$11.4M
Molecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0M
Mechanisms of mitochondrial calcium exchange in heart failureR01HL123966 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2014 to 2018
$2.3M
Mitochondria and metabolism in neurodegenerationRF1NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2021 to 2021
$2.3M
NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL123966NHLBI NIH HHS R01 HL142271NINDS NIH HHS RF1 NS121379
6 · The paper itself

Abstract

Heart failure (HF) is a leading cause of hospitalization and mortality worldwide. Yet, there is still limited knowledge on the underlying molecular mechanisms, because human tissue for research is scarce, and data obtained in animal models is not directly applicable to humans. Thus, studies of human heart specimen are of particular relevance. Mitochondrial Ca

Indexed as

Cation Transport ProteinsMitochondrial Membrane Transport ProteinsAnimalsCalciumCalcium-Binding ProteinsHumansMitochondriaCalciumCalcium-Binding ProteinsCation Transport ProteinsMitochondrial Membrane Transport ProteinscardiomyopathyHeart failureHFrEFHuman cardiac biopsyMICU1MICU2Mitochondrial Ca2+ signalingMitochondrial calcium uniporter

Identifiers

PMID35779476
PMCPMC10446164
OpenAlexW4283378917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.